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Mechanisms of acute cocaine toxicity
| Content Provider | PubMed Central |
|---|---|
| Author | Heard, Kennon Palmer, Robert Zahniser, Nancy R. |
| Abstract | Patients with acute cocaine poisoning present with life-threatening symptoms involving several organ systems. While the effects of cocaine are myriad, they are the result of a limited number of cocaine-protein interactions, including monoamine transporters, neurotransmitter receptors and voltage-gated ion channels. These primary interactions trigger a cascade of events that ultimately produce the clinical effects. The purpose of this article is to review the primary interactions of cocaine and the effects that these interactions trigger. We also describe the progression of symptoms observed in cocaine poisoning as they relate to serum cocaine concentrations. |
| Related Links | http://dx.doi.org/10.2174/1874143600802010070 |
| Starting Page | 70 |
| File Format | |
| ISSN | 18741436 |
| e-ISSN | 18741436 |
| Journal | The open pharmacology journal |
| Issue Number | 9 |
| Volume Number | 2 |
| Language | English |
| Publisher Date | 2008-01-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology Molecular Medicine Pharmaceutical Science |
