NDLI: Transcriptional regulation shapes the organization of genes on bacterial chromosomes

Content Provider	PubMed Central
Author	Janga, Sarath Chandra Salgado, Heladia Agustino, Martínez-antonio
Copyright Year	2009
Abstract	Transcription factors (TFs) are the key elements responsible for controlling the expression of genes in bacterial genomes and when visualized on a genomic scale form a dense network of transcriptional interactions among themselves and with other protein coding genes. Although the structure of transcriptional regulatory networks (TRNs) is well understood, it is not clear what constrains govern them. Here, we explore this question using the TRNs of model prokaryotes and provide a link between the transcriptional hierarchy of regulons and their genome organization. We show that, to drive the kinetics and concentration gradients, TFs belonging to big and small regulons, depending on the number of genes they regulate, organize themselves differently on the genome with respect to their targets. We then propose a conceptual model that can explain how the hierarchical structure of TRNs might be ultimately governed by the dynamic biophysical requirements for targeting DNA-binding sites by TFs. Our results suggest that the main parameters defining the position of a TF in the network hierarchy are the number and chromosomal distances of the genes they regulate and their protein concentration gradients. These observations give insights into how the hierarchical structure of transcriptional networks can be encoded on the chromosome to drive the kinetics and concentration gradients of TFs depending on the number of genes they regulate and could be a common theme valid for other prokaryotes, proposing the role of transcriptional regulation in shaping the organization of genes on a chromosome.
Related Links	http://dx.doi.org/10.1093/nar/gkp231
Starting Page	3680
File Format	PDF
ISSN	13624962
e-ISSN	13624962
Journal	Nucleic Acids Research
Issue Number	11
Volume Number	37
Language	English
Publisher	Oxford University Press
Publisher Date	2009-06-01
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Transcriptional regulation shapes the organization of genes on bacterial chromosomes

Transcriptional regulation constrains the organization of genes on eukaryotic chromosomes

The effects of Arabidopsis genome duplication on the chromatin organization and transcriptional regulation

Transcriptional regulation of mammalian miRNA genes

Transcriptional regulation of immunoglobulin V genes.

Organization and segregation of bacterial chromosomes

Deciphering the transcriptional regulation of microRNA genes in humans with ACTLocater

Transcriptional regulation of the Drosophila moira and osa genes by the DREF pathway

Promoter RNA links transcriptional regulation of inflammatory pathway genes

Transcriptional regulation shapes the organization of genes on bacterial chromosomes

Similar Documents

Transcriptional regulation shapes the organization of genes on bacterial chromosomes

Transcriptional regulation constrains the organization of genes on eukaryotic chromosomes

The effects of Arabidopsis genome duplication on the chromatin organization and transcriptional regulation

Transcriptional regulation of mammalian miRNA genes

Transcriptional regulation of immunoglobulin V genes.

Organization and segregation of bacterial chromosomes

Deciphering the transcriptional regulation of microRNA genes in humans with ACTLocater

Transcriptional regulation of the Drosophila moira and osa genes by the DREF pathway

Promoter RNA links transcriptional regulation of inflammatory pathway genes

Transcriptional regulation shapes the organization of genes on bacterial chromosomes