NDLI: Neuronal activity and Wnt signaling act through Gsk3-β to regulate axonal integrity in mature Drosophila olfactory sensory neurons

Content Provider	PubMed Central
Author	Chiang, Albert Priya, Rashi Ramaswami, Mani Vijayraghavan, K. Rodrigues, Veronica
Abstract	The roles played by signaling pathways and neural activity during the development of circuits have been studied in several different contexts. However, the mechanisms involved in maintaining neuronal integrity once circuits are established are less well understood, despite their potential relevance to neurodegeneration. We demonstrate that maintenance of adult Drosophila olfactory sensory neurons requires cell-autonomous neuronal activity. When activity is silenced, development occurs normally, but neurons degenerate in adulthood. These detrimental effects can be compensated by downregulating Glycogen synthase kinase-3β (Gsk-3β). Conversely, ectopic expression of activated Gsk-3β or downregulation of Wnt effectors also affect neuron stability, demonstrating a role for Wnt signaling in neuroprotection. This is supported by our observation that activated adult neurons are capable of increased Wingless release, and its targeted expression can protect neurons against degeneration. The role of Wnt signaling in this process is non-transcriptional, and may act on cellular mechanisms that regulate axonal or synaptic stability. Together, we provide evidence that Gsk-3β is a key sensor involved in neural circuit integrity, maintaining axon stability through neural activity and the Wnt pathway.
Related Links	http://dx.doi.org/10.1242/dev.031377
Ending Page	1282
Page Count	10
Starting Page	1273
File Format	PDF
ISSN	09501991
e-ISSN	14779129
Journal	Development (Cambridge, England)
Issue Number	8
Volume Number	136
Language	English
Publisher	Company of Biologists
Publisher Date	2009-04-15
Access Restriction	Open
Rights Holder	Company of Biologists
Subject Keyword	Developmental Biology Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Developmental Biology Molecular Biology

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