NDLI: Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

Content Provider	PubMed Central
Author	Varambally, Sooryanarayana Cao, Qi Mani, Ram-shankar Shankar, Sunita Wang, Xiaosong Ateeq, Bushra Laxman, Bharathi Cao, Xuhong Jing, Xiaojun Kalpana, Ramnarayanan Brenner, J. Chad Yu, Jindan Kim, Jung H. Han, Bo Tan, Patrick Chandan, Kumar-sinha Lonigro, Robert J. Palanisamy, Nallasivam Maher, Christopher A. Chinnaiyan, Arul M.
Abstract	Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and that regulates the survival and metastasis of cancer cells. EZH2 is overexpressed in aggressive solid tumors by mechanisms that remain unclear. Here, we show that the expression and function of EZH2 in cancer cell lines is inhibited by microRNA-101 (miR-101). Analysis of human prostate tumors revealed that miR-101 expression decreases during cancer progression, paralleling an increase in EZH2 expression. One or both of the two genomic loci encoding miR-101 were somatically lost in 37.5% of clinically localized prostate cancers (6/16) and 66.7% of metastatic disease (22/33). We propose that genomic loss of miR-101 in cancer leads to overexpression of EZH2 and concomitant dysregulation of epigenetic pathways, resulting in cancer progression.
Related Links	http://dx.doi.org/10.1126/science.1165395
Ending Page	1699
Page Count	5
Starting Page	1695
File Format	PDF
ISSN	00368075
e-ISSN	10959203
Journal	Science (New York, N.Y.)
Issue Number	5908
Volume Number	322
Language	English
Publisher Date	2008-12-12
Access Restriction	Open
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	History and Philosophy of Science

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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