NDLI: Implications of vaccination and waning immunity

Content Provider	PubMed Central
Author	Heffernan, J. M. Keeling, M. J.
Copyright Year	2009
Abstract	For infectious diseases where immunization can offer lifelong protection, a variety of simple models can be used to explain the utility of vaccination as a control method. However, for many diseases, immunity wanes over time and is subsequently enhanced (boosted) by asymptomatic encounters with the infection. The study of this type of epidemiological process requires a model formulation that can capture both the within-host dynamics of the pathogen and immune system as well as the associated population-level transmission dynamics. Here, we parametrize such a model for measles and show how vaccination can have a range of unexpected consequences as it reduces the natural boosting of immunity as well as reducing the number of naive susceptibles. In particular, we show that moderate waning times (40–80 years) and high levels of vaccination (greater than 70%) can induce large-scale oscillations with substantial numbers of symptomatic cases being generated at the peak. In addition, we predict that, after a long disease-free period, the introduction of infection will lead to far larger epidemics than that predicted by standard models. These results have clear implications for the long-term success of any vaccination campaign and highlight the need for a sound understanding of the immunological mechanisms of immunity and vaccination.
Related Links	http://dx.doi.org/10.1098/rspb.2009.0057
Ending Page	2080
Page Count	10
Starting Page	2071
File Format	PDF
ISSN	09628452
e-ISSN	14712954
Journal	Proceedings of the Royal Society B: Biological Sciences
Issue Number	1664
Volume Number	276
Language	English
Publisher	The Royal Society
Publisher Date	2009-06-07
Access Restriction	Open
Rights Holder	The Royal Society
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Agricultural and Biological Sciences(all) Environmental Science(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology Environmental Science Agricultural and Biological Sciences

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Implications of vaccination and waning immunity

Pathogen adaptation under imperfect vaccination: implications for pertussis

Bateman's principle and immunity.

Reactive vaccination in the presence of disease hotspots

Microparasite population dynamics and continuous immunity.

Imitation dynamics of vaccination behaviour on social networks

Complex environmental drivers of immunity and resistance in malaria mosquitoes

Network frailty and the geometry of herd immunity

The evolution of resistance through costly acquired immunity.

Implications of vaccination and waning immunity

Similar Documents

Implications of vaccination and waning immunity

Pathogen adaptation under imperfect vaccination: implications for pertussis

Bateman's principle and immunity.

Reactive vaccination in the presence of disease hotspots

Microparasite population dynamics and continuous immunity.

Imitation dynamics of vaccination behaviour on social networks

Complex environmental drivers of immunity and resistance in malaria mosquitoes

Network frailty and the geometry of herd immunity

The evolution of resistance through costly acquired immunity.

Implications of vaccination and waning immunity