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| Content Provider | PubMed Central |
|---|---|
| Author | Yang, Jilong Du, Xiaoling Chen, Kexin Antti, Ylipaa Lazar, Alexander J. F. Trent, Jonathan Lev, Dina Pollock, Raphael Hao, Xishan Hunt, Kelly Zhang, Wei |
| Abstract | Leiomyosarcoma is a malignant mesenchymal tumor composed of cells showing smooth muscle differentiation. This tumor usually occurs in middle-aged or older adults, and forms a significant percentage of retroperitoneal, vascular, extremity and uterine sarcomas. Leiomyosarcomas are most often associated with complex karyotypes with numerous chromosomal gains and losses. Some of these cytogenetic and molecular genetic aberrations correlate with histopathologic features and clinical outcomes. Identification of genetic alterations with specific identification of oncogenes and tumor suppressor genes may lead to additional insights into the tumorigenesis of leiomyosarcoma and the opportunity to confer the benefits of targeted therapy. |
| Related Links | http://dx.doi.org/10.1016/j.canlet.2008.06.013 |
| Ending Page | 8 |
| Page Count | 8 |
| Starting Page | 1 |
| File Format | |
| ISSN | 03043835 |
| e-ISSN | 18727980 |
| Journal | Cancer letters |
| Issue Number | 1 |
| Volume Number | 275 |
| Language | English |
| Publisher Date | 2009-03-01 |
| Access Restriction | Open |
| Subject Keyword | Cancer Research Oncology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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