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| Content Provider | PubMed Central |
|---|---|
| Author | Hughes, Michael E. Ditacchio, Luciano Hayes, Kevin Pullivarthy, Sandhya R. Panda, Satchidananda Hogenesch, John |
| Abstract | In both the suprachiasmatic nucleus and peripheral tissues, the circadian oscillator drives rhythmic transcription of downstream target genes. Recently, a number of studies have used DNA microarrays to systematically identify oscillating transcripts in plants, fruit flies, rats and mice. These studies have identified several dozen to many hundred rhythmically expressed genes by sampling tissues every four hours for one, two, or more days. To extend this work, we have performed DNA microarray analysis on RNA derived from the mouse pituitary sampled every hour for two days. COSOPT and Fisher's G-test were employed at a false-discovery rate less than 5% to identify more than 250 genes in the pituitary that oscillate with a 24-hour period length. We found that increasing the frequency of sampling across the circadian day dramatically increased the statistical power of both COSOPT and Fisher's G-test, resulting in considerably more high-confidence identifications of rhythmic transcripts than previously described. Finally, to extend the utility of these data sets, a web-based resource has been constructed at http://wasabi.itmat.upenn.edu/circa/mouse that is freely available to the research community. |
| Related Links | http://dx.doi.org/10.1101/sqb.2007.72.011 |
| Starting Page | 381 |
| File Format | |
| ISSN | 19434456 |
| e-ISSN | 19434456 |
| Journal | Cold Spring Harbor symposia on quantitative biology |
| Volume Number | 72 |
| Language | English |
| Publisher Date | 2007-01-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Biochemistry Molecular Biology |
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