NDLI: NKCC1 (SLC12a2) induces a secondary axis in Xenopus laevis embryos independently of its co-transporter function

Content Provider	PubMed Central
Author	Walters, Zoë S. Haworth, Kim E. Latinkic, Branko V.
Copyright Year	2009
Abstract	NKCC1 is a broadly expressed Na+–K+–Cl− co-transporter involved in regulation of ion flux across the cell membrane and in regulating cell volume. Whilst much is known about the co-transporter activity of NKCC1 and its regulation by protein kinases and phosphatases, little is known about the activities of NKCC1 that are co-transporter independent. In this report we show that over-expression of NKCC1 in embryos of Xenopus laevis induces secondary axes, independently of its co-transporter activity. In addition, over-expression of NKCC1 results in the formation of neural tissue in ectodermal explants. We also show that NKCC1 is expressed broadly but non-uniformly in embryos of Xenopus laevis and Xenopus tropicalis, with prominent expression in the notochord, nervous system and stomach. These results provide insights into an additional, previously unreported activity of NKCCl.
Related Links	http://dx.doi.org/10.1113/jphysiol.2008.161562
Ending Page	529
Page Count	9
Starting Page	521
File Format	PDF
ISSN	00223751
e-ISSN	14697793
Journal	The Journal of Physiology
Issue Number	Pt 3
Volume Number	587
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2009-02-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

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NKCC1 (SLC12a2) induces a secondary axis in Xenopus laevis embryos independently of its co-transporter function