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  1. Tobacco Induced Diseases
  2. Year: 2002, Volume: 1
  3. Year: 2002, Volume: 1, Issue: 1
  4. The influence of tobacco smoking on adhesion molecule profiles
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Year: 2002, Volume: 1, Issue: 1
Centuries of suffering from a preventable cause: where is that human intelligence?
The influence of tobacco smoking on adhesion molecule profiles
Tobacco advertising and the art and science of persuasion
Analysis of circulating insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) in tobacco smokers and non-smokers
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The influence of tobacco smoking on adhesion molecule profiles

Content Provider PubMed Central
Author Scott, Da Palmer, Rm
Copyright Year 2003
Abstract Sequential interactions between several adhesion molecules and their ligands regulate lymphocyte circulation and leukocyte recruitment to inflammatory foci. Adhesion molecules are, therefore, central and critical components of the immune and inflammatory system. We review the evidence that tobacco smoking dysregulates specific components of the adhesion cascade, which may be a common factor in several smoking-induced diseases. Smoking causes inappropriate leukocyte activation, leukocyte-endothelial adhesion, and neutrophil entrapment in the microvasculature, which may help initiate local tissue destruction. Appropriate inflammatory reactions may thus be compromised. In addition to smoke-induced alterations to membrane bound endothelial and leukocyte adhesion molecule expression, which may help explain the above phenomena, smoking has a profound influence on circulating adhesion molecule profiles, most notably sICAM-1 and specific sCD44 variants. Elevated concentrations of soluble adhesion molecules may simply reflect ongoing inflammatory processes. However, increasing evidence suggests that specific soluble adhesion molecules are immunomodulatory, and that alterations to soluble adhesion molecule profiles may represent a significant risk factor for several diverse diseases. This evidence is discussed herein.
Related Links http://dx.doi.org/10.1186/1617-9625-1-3
Starting Page 3
File Format PDF
ISSN 16179625
e-ISSN 16179625
Journal Tobacco Induced Diseases
Issue Number 1
Volume Number 1
Language English
Publisher BioMed Central
Publisher Date 2002-01-15
Access Restriction Open
Rights Holder BioMed Central
Subject Keyword Research in Higher Education
Content Type Text
Resource Type Article
Subject Health (social science) Public Health, Environmental and Occupational Health
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