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| Content Provider | PubMed Central |
|---|---|
| Author | Scott, Da Palmer, Rm |
| Copyright Year | 2003 |
| Abstract | Sequential interactions between several adhesion molecules and their ligands regulate lymphocyte circulation and leukocyte recruitment to inflammatory foci. Adhesion molecules are, therefore, central and critical components of the immune and inflammatory system. We review the evidence that tobacco smoking dysregulates specific components of the adhesion cascade, which may be a common factor in several smoking-induced diseases. Smoking causes inappropriate leukocyte activation, leukocyte-endothelial adhesion, and neutrophil entrapment in the microvasculature, which may help initiate local tissue destruction. Appropriate inflammatory reactions may thus be compromised. In addition to smoke-induced alterations to membrane bound endothelial and leukocyte adhesion molecule expression, which may help explain the above phenomena, smoking has a profound influence on circulating adhesion molecule profiles, most notably sICAM-1 and specific sCD44 variants. Elevated concentrations of soluble adhesion molecules may simply reflect ongoing inflammatory processes. However, increasing evidence suggests that specific soluble adhesion molecules are immunomodulatory, and that alterations to soluble adhesion molecule profiles may represent a significant risk factor for several diverse diseases. This evidence is discussed herein. |
| Related Links | http://dx.doi.org/10.1186/1617-9625-1-3 |
| Starting Page | 3 |
| File Format | |
| ISSN | 16179625 |
| e-ISSN | 16179625 |
| Journal | Tobacco Induced Diseases |
| Issue Number | 1 |
| Volume Number | 1 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2002-01-15 |
| Access Restriction | Open |
| Rights Holder | BioMed Central |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health (social science) Public Health, Environmental and Occupational Health |
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