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Hormonal treatment, mild cognitive impairment and Alzheimer's disease
| Content Provider | PubMed Central |
|---|---|
| Author | Ryan, Joanne Scali, Jaqueline Carriere, Isabelle Ritchie, Karen Ancelin, Marie-laure |
| Abstract | A plethora of in vitro and in vivo studies have supported the neuroprotective role of estrogens and their impact on the neurotransmitter systems implicated in cognition. Recent hormonal replacement therapy trials in non-demented post-menopausal women suggest a temporary positive effect (notably on verbal memory), and four meta-analyses converge to suggest a possible protective effect in relation to Alzheimer’s disease (reducing risk by 29 to 44%). However, data from the only large randomized controlled trial published to date, the Women’s Health Initiative Memory Study, did not confirm these observations and have even suggested an increase in dementia risk for women using hormonal replacement therapy compared to controls. Apart from methodological differences, one key short-coming of this trial has probably been the focus on late-onset (postmenopausal) hormonal changes, i.e. at a time when the neurodegenerative process has already begun and without taking into account individual lifetime exposure to hormone variability. Multifactorial models based on an exhaustive view of all hormonal events throughout the reproductive life (rather than on a specific exposure to a given steroid) together with other risk factors (notably genetic risk factors related to estrogen receptor polymorphisms) should be explored to clarify the role of hormonal risk factors, or protective factors for cognitive dysfunction and dementia. |
| Related Links | http://dx.doi.org/10.1017/s1041610207006485 |
| Starting Page | 47 |
| File Format | |
| ISSN | 10416102 |
| e-ISSN | 1741203X |
| Journal | International Psychogeriatrics / Ipa |
| Issue Number | 1 |
| Volume Number | 20 |
| Language | English |
| Publisher | Springer Publishing |
| Publisher Date | 2008-02-01 |
| Access Restriction | Open |
| Rights Holder | Springer Publishing |
| Subject Keyword | Gerontology Clinical Psychology Geriatrics and Gerontology Psychiatry and Mental health Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Gerontology Clinical Psychology Geriatrics and Gerontology Psychiatry and Mental Health |
