NDLI: Can We Develop Genetically Tractable Models to Assess Healthspan (Rather Than Life Span) in Animal Models?

Content Provider	PubMed Central
Author	Tatar, Marc
Copyright Year	2009
Abstract	Understanding healthspan is arguably the most relevant clinical, social, and economic feature of aging research. The model systems of worm, fly, and mouse are potentially powerful tools to achieve this aim. These models provide two unique approaches. The first is based on genetic screening for gain or loss of function mutations that ameliorate senescence. Genetic factors discovered by this process permit us to recognize causal and regulatory mechanisms of aging. A related screen looks for compounds that slow aging or act upon proteins that were initially identified from genetic analysis. The second research strategy uses manipulations of targeted genetic factors to test causal explanations for aging. These studies include transgenic organisms and genetic epistasis analysis. Overall, genetically driven research with model organisms is largely responsible for the breakthrough of aging biology in the past 15 years. Aging in these contexts, however, has been measured almost exclusively from cohort survival statistics such as life expectancy and age-specific mortality. This is for a good reason. Manipulated factors that extend life span are thought to unambiguously slow senescence and thus to reflect underlying causes of the aging process. But this approach is also common for a practical reason—healthspan is a poorly defined commodity in humans, let alone for genetic animal model systems. It was the consensus of the working session that making healthspan an operational metric would be an innovation needed for the genetic power of model systems to address this aspect of human aging.
Related Links	http://dx.doi.org/10.1093/gerona/gln067
Ending Page	163
Page Count	3
Starting Page	161
File Format	PDF
ISSN	10795006
e-ISSN	1758535X
Journal	The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Issue Number	2
Volume Number	64A
Language	English
Publisher	Oxford University Press
Publisher Date	2009-02-01
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Ageing Geriatrics and Gerontology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Aging Geriatrics and Gerontology

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