NDLI: Uneven Distribution of Mating Types among Genotypes of Candida glabrata Isolates from Clinical Samples▿ †

Content Provider	PubMed Central
Author	Sylvain, Brisse Pannier, Christine Angoulvant, Adela Meeus, Thierry De Laure, Diancourt Faure, Odile Muller, Héloïse Peman, Javier Viviani, Maria Anna Grillot, Renée Dujon, Bernard Fairhead, Cécile Hennequin, Christophe
Abstract	In order to shed light on its basic biology, we initiated a population genetic analysis of Candida glabrata, an emerging pathogenic yeast with no sexual stage yet recognized. A worldwide collection of clinical strains was subjected to analysis using variable number of tandem repeats (VNTR) at nine loci. The clustering of strains obtained with this method was congruent with that obtained using sequence polymorphism of the NMT1 gene, a locus previously proposed for lineage assignment. Linkage disequilibrium supported the hypothesis of a mainly clonal reproduction. No heterozygous diploid genotype was found. Minimum-spanning tree analysis of VNTR data revealed clonal expansions and associated genotypic diversification. Mating type analysis revealed that 80% of the strains examined are MAT a and 20% MATα and that the two alleles are not evenly distributed. The MAT a genotype dominated within large clonal groups that contained only one or a few MATα types. In contrast, two groups were dominated by MATα strains. Our data are consistent with rare independent mating type switching events occurring preferentially from type a to α, although the alternative possibility of selection favoring type a isolates cannot be excluded.
Related Links	http://dx.doi.org/10.1128/EC.00215-08
Starting Page	287
File Format	PDF
ISSN	15359786
e-ISSN	15359786
Journal	Eukaryotic Cell
Issue Number	3
Volume Number	8
Language	English
Publisher	American Society for Microbiology (ASM)
Publisher Date	2009-03-01
Access Restriction	Open
Rights Holder	American Society for Microbiology (ASM)
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Microbiology

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The Asexual Yeast Candida glabrata Maintains Distinct a and α Haploid Mating Types

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