NDLI: Rembrandt: Helping Personalized Medicine Become a Reality Through Integrative Translational Research

Please wait, while we are loading the content...

Year: 2016, Volume: 14

Year: 2015, Volume: 13

Year: 2014, Volume: 12

Year: 2013, Volume: 11

Year: 2012, Volume: 10

Year: 2011, Volume: 9

Year: 2010, Volume: 8

Year: 2009, Volume: 7

Year: 2009, Volume: 7, Issue: 12

Year: 2009, Volume: 7, Issue: 11

Year: 2009, Volume: 7, Issue: 10

Year: 2009, Volume: 7, Issue: 9

Year: 2009, Volume: 7, Issue: 8

Year: 2009, Volume: 7, Issue: 7

Year: 2009, Volume: 7, Issue: 6

Year: 2009, Volume: 7, Issue: 5

Year: 2009, Volume: 7, Issue: 4

Year: 2009, Volume: 7, Issue: 3

Year: 2009, Volume: 7, Issue: 2

Rembrandt: Helping Personalized Medicine Become a Reality Through Integrative Translational Research

Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy

YY1 modulates taxane response in epithelial ovarian cancer

YY1 regulates the expression of snail through a distal enhancer

KRAS2 Mutations in Human Pancreatic Acinar-Ductal Metaplastic Lesions are Limited to those with PanIN: Implications for the Human Pancreatic Cancer Cell of Origin

REV1 is implicated in the development of carcinogen-induced lung cancer

ANASTELLIN, THE ANGIOSTATIC FIBRONECTIN PEPTIDE, IS A SELECTIVE INHIBITOR OF LYSOPHOSPHOLIPID SIGNALING

Year: 2009, Volume: 7, Issue: 1

Year: 2008, Volume: 6

Year: 2007, Volume: 5

Year: 2005, Volume: 3

Rembrandt: Helping Personalized Medicine Become a Reality Through Integrative Translational Research

Content Provider	PubMed Central
Author	Madhavan, Subha Zenklusen, Jean-claude Yuri, Kotliarov Sahni, Himanso Fine, Howard A. Buetow, Kenneth
Abstract	Finding better therapies for the treatment of brain tumors is hampered by the lack of consistently obtained molecular data in a large sample set, and ability to integrate biomedical data from disparate sources enabling translation of therapies from bench to bedside. Hence, a critical factor in the advancement of biomedical research and clinical translation is the ease with which data can be integrated, redistributed and analyzed both within and across functional domains. Novel biomedical informatics infrastructure and tools are essential for developing individualized patient treatment based on the specific genomic signatures in each patient’s tumor. Here we present Rembrandt, Repository of Molecular BRAin Neoplasia DaTa, a cancer clinical genomics database and a web-based data mining and analysis platform aimed at facilitating discovery by connecting the dots between clinical information and genomic characterization data. To date, Rembrandt contains data generated through the Glioma Molecular Diagnostic Initiative from 874 glioma specimens comprising nearly 566 gene expression arrays, 834 copy number arrays and 13,472 clinical phenotype data points. Data can be queried and visualized for a selected gene across all data platforms or for multiple genes in a selected platform. Additionally, gene sets can be limited to clinically important annotations including secreted, kinase, membrane, and known gene-anomaly pairs to facilitate the discovery of novel biomarkers and therapeutic targets. We believe that REMBRANDT represents a prototype of how high throughput genomic and clinical data can be integrated in a way that will allow expeditious and efficient translation of laboratory discoveries to the clinic.
Related Links	http://dx.doi.org/10.1158/1541-7786.mcr-08-0435
Ending Page	167
Page Count	11
Starting Page	157
File Format	PDF
ISSN	15417786
Journal	Molecular cancer research : MCR
Issue Number	2
Volume Number	7
Language	English
Publisher Date	2009-02-01
Access Restriction	Open
Subject Keyword	Cancer Research Oncology Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Cancer Research Oncology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in