NDLI: Retuning of Inferior Colliculus Neurons Following Spiral Ganglion Lesions: A Single-Neuron Model of Converging Inputs

Content Provider	PubMed Central
Author	Sumner, Christian J. Scholes, Chris Snyder, Russell L.
Abstract	Lesions of spiral ganglion cells, representing a restricted sector of the auditory nerve array, produce immediate changes in the frequency tuning of inferior colliculus (IC) neurons. There is a loss of excitation at the lesion frequencies, yet responses to adjacent frequencies remain intact and new regions of activity appear. This leads to immediate changes in tuning and in tonotopic progression. Similar effects are seen after different methods of peripheral damage and in auditory neurons in other nuclei. The mechanisms that underlie these postlesion changes are unknown, but the acute effects seen in IC strongly suggest the “unmasking” of latent inputs by the removal of inhibition. In this study, we explore computational models of single neurons with a convergence of excitatory and inhibitory inputs from a range of characteristic frequencies (CFs), which can simulate the narrow prelesion tuning of IC neurons, and account for the changes in CF tuning after a lesion. The models can reproduce the data if inputs are aligned relative to one another in a precise order along the dendrites of model IC neurons. Frequency tuning in these neurons approximates that seen physiologically. Removal of inputs representing a narrow range of frequencies leads to unmasking of previously subthreshold excitatory inputs, which causes changes in CF. Conversely, if all of the inputs converge at the same point on the cell body, receptive fields are broad and unmasking rarely results in CF changes. However, if the inhibition is tonic with no stimulus-driven component, then unmasking can still produce changes in CF.
Related Links	http://dx.doi.org/10.1007/s10162-008-0139-6
Ending Page	130
Page Count	20
Starting Page	111
File Format	PDF
ISSN	15253961
e-ISSN	14387573
Journal	JARO: Journal of the Association for Research in Otolaryngology
Issue Number	1
Volume Number	10
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-03-01
Access Restriction	Open
Rights Holder	Springer-Verlag
Subject Keyword	Sensory Systems Otorhinolaryngology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology Sensory Systems

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