NDLI: C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia

Content Provider	PubMed Central
Author	Yamasaki, Sho Matsumoto, Makoto Takeuchi, Osamu Matsuzawa, Tetsuhiro Ishikawa, Eri Sakuma, Machie Tateno, Hiroaki Uno, Jun Hirabayashi, Jun Mikami, Yuzuru Takeda, Kiyoshi Akira, Shizuo Saito, Takashi
Abstract	Mincle (also called as Clec4e and Clecsf9) is a C-type lectin receptor expressed in activated phagocytes. Recently, we have demonstrated that Mincle is an FcRγ-associated activating receptor that senses damaged cells. To search an exogenous ligand(s), we screened pathogenic fungi using cell line expressing Mincle, FcRγ, and NFAT-GFP reporter. We found that Mincle specifically recognizes the Malassezia species among 50 different fungal species tested. Malassezia is a pathogenic fungus that causes skin diseases, such as tinea versicolor and atopic dermatitis, and fatal sepsis. However, the specific receptor on host cells has not been identified. Mutation of the putative mannose-binding motif within C-type lectin domain of Mincle abrogated Malassezia recognition. Analyses of glycoconjugate microarray revealed that Mincle selectively binds to α-mannose but not mannan. Thus, Mincle may recognize specific geometry of α-mannosyl residues on Malassezia species and use this to distinguish them from other fungi. Malassezia activated macrophages to produce inflammatory cytokines/chemokines. To elucidate the physiological function of Mincle, Mincle-deficient mice were established. Malassezia-induced cytokine/chemokine production by macrophages from Mincle−/− mice was significantly impaired. In vivo inflammatory responses against Malassezia was also impaired in Mincle−/− mice. These results indicate that Mincle is the first specific receptor for Malassezia species to be reported and plays a crucial role in immune responses to this fungus.
Related Links	http://dx.doi.org/10.1073/pnas.0805177106
Ending Page	1902
Page Count	6
Starting Page	1897
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	106
Language	English
Publisher	National Academy of Sciences
Publisher Date	2009-02-10
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Rat Macrophage C-Type Lectin Is an Activating Receptor Expressed by Phagocytic Cells

Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans

Self and nonself recognition through C-type lectin receptor, Mincle

Characterisation of the bovine C-type lectin receptor Mincle and potential evidence for an endogenous ligand

Characterisation of the bovine C-type lectin receptor Mincle and potential evidence for an endogenous ligand1

The C-Type Lectin Receptor Mincle Binds to Streptococcus pneumoniae but Plays a Limited Role in the Anti-Pneumococcal Innate Immune Response

The C-Type Lectin Mincle: Clues for a Role in Crohn’s Disease Adjuvant Reaction

Defining the conformation of human mincle that interacts with mycobacterial trehalose dimycolate

Glycerol Monomycolate Is a Novel Ligand for the Human, but Not Mouse Macrophage Inducible C-type Lectin, Mincle*

C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia

Similar Documents

Rat Macrophage C-Type Lectin Is an Activating Receptor Expressed by Phagocytic Cells

Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans

Self and nonself recognition through C-type lectin receptor, Mincle

Characterisation of the bovine C-type lectin receptor Mincle and potential evidence for an endogenous ligand

Characterisation of the bovine C-type lectin receptor Mincle and potential evidence for an endogenous ligand1

The C-Type Lectin Receptor Mincle Binds to Streptococcus pneumoniae but Plays a Limited Role in the Anti-Pneumococcal Innate Immune Response

The C-Type Lectin Mincle: Clues for a Role in Crohn’s Disease Adjuvant Reaction

Defining the conformation of human mincle that interacts with mycobacterial trehalose dimycolate

Glycerol Monomycolate Is a Novel Ligand for the Human, but Not Mouse Macrophage Inducible C-type Lectin, Mincle*

C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia