NDLI: Increased glial glutamate transporter EAAT2 expression reduces visceral nociceptive response in mice

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Increased glial glutamate transporter EAAT2 expression reduces visceral nociceptive response in mice

Year: 2008, Volume: 295

Year: 2008, Volume: 294

Increased glial glutamate transporter EAAT2 expression reduces visceral nociceptive response in mice

Content Provider	PubMed Central
Author	Lin, Yuan Tian, Guilian Roman, Kenny Handy, Chalonda Travers, Joseph B. Lin, Chien-liang Glenn Stephens, Robert L.
Copyright Year	2009
Abstract	Visceral hypersensitivity is the leading complaint of functional bowel disorders. Central sensitization mediated by glutamate receptor activation is implicated in pathophysiology of visceral pain. The glial glutamate transporter EAAT2 is the principal mediator of glutamate clearance to terminate glutamate-mediated responses. Transgenic mice overexpressing human EAAT2 (EAAT2 mice), which exhibited a twofold enhanced glutamate uptake, showed 39% less writhing response to intraperitoneal acetic acid than nontransgenic littermates. Moreover, EAAT2 transgenic mice showed a 53–64% reduction in visceromotor response (VMR) to colorectal distension (CRD) in assessments of the response to graded increase in pressures. Corroborating the involvement of enhanced glutamate uptake, wild-type mice treated for 1 wk with ceftriaxone, an EAAT2 expression activator, showed a 49–70% reduction in VMR to CRD. Moreover, systemic pretreatment with the selective EAAT2 transporter blocker dihydrokainate reversed the ceftriaxone-blunted nociceptive response to CRD. However, the enhanced VMR to CRD produced by intracolonic ethanol was not significantly attenuated by 1-wk ceftriaxone pretreatment. The data suggest that enhanced glutamate uptake provides protective effects against colonic distension-induced nociception and represents an exciting new mechanistic approach leading to better therapeutic options to visceral pain disorders.
Related Links	http://dx.doi.org/10.1152/ajpgi.90556.2008
Starting Page	129
File Format	PDF
ISSN	01931857
e-ISSN	15221547
Journal	American Journal of Physiology - Gastrointestinal and Liver Physiology
Issue Number	1
Volume Number	296
Language	English
Publisher	American Physiological Society
Publisher Date	2008-11-01
Access Restriction	Open
Rights Holder	American Physiological Society
Subject Keyword	Hepatology Gastroenterology Physiology (medical) Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Hepatology Physiology Physiology (medical) Gastroenterology

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