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Amino acid transporters and nutrient sensing mechanisms

Content Provider	PubMed Central
Author	Reynolds, Bruno Robert, Laynes Ögmundsdóttir, Margrét H. Boyd, C. A. Richard Goberdhan, Deborah C. I.
Abstract	The insulin/IGF signalling (IIS) cascade has an important role in regulating normal development and physiology, as evidenced by its effects in a host of major human diseases including cancer, Type II diabetes and neurodegeneration. Recently it has become clear that multiple types of local nutrient sensing mechanism impact on cellular insulin sensitivity through the downstream kinase TOR (target of rapamycin). In vivo analysis in flies has surprisingly highlighted proton-assisted amino acid transporters as having a uniquely potent role in regulating IIS/TOR activity and growth, potentially via a novel signalling mechanism. Other molecules such as the heterodimeric amino acid transporter, CD98, which provides the principal route for cellular uptake of leucine, an amino acid implicated in regulating TOR, also appear to have important effects. As our understanding of how nutrient sensing impacts on IIS/TOR increases, novel targets to modulate aberrant IIS in disease are likely to emerge, which could complement current strategies designed to block kinases in this pathway.
Related Links	http://dx.doi.org/10.1042/bst0351215
Ending Page	1217
Page Count	3
Starting Page	1215
File Format	PDF
ISSN	03005127
e-ISSN	14708752
Journal	Biochemical Society transactions
Issue Number	Pt 5
Volume Number	35
Language	English
Publisher Date	2007-11-01
Access Restriction	Open
Subject Keyword	Biochemistry Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biochemistry

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