NDLI: Neuropsychological Functioning in Adolescents and Young Adults at Genetic Risk for Schizophrenia and Affective Psychoses: Results from the Harvard and Hillside Adolescent High Risk Studies

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Neuropsychological Functioning in Adolescents and Young Adults at Genetic Risk for Schizophrenia and Affective Psychoses: Results from the Harvard and Hillside Adolescent High Risk Studies

Year: 2006, Volume: 32, Issue: 2

Year: 2006, Volume: 32, Issue: 1

Year: 2005, Volume: 32

Year: 2003, Volume: 29

Year: 2001, Volume: 27

Neuropsychological Functioning in Adolescents and Young Adults at Genetic Risk for Schizophrenia and Affective Psychoses: Results from the Harvard and Hillside Adolescent High Risk Studies

Content Provider	PubMed Central
Author	Seidman, Larry J. Giuliano, Anthony J. Smith, Christopher W. Stone, William S. Glatt, Stephen J. Meyer, Eric Faraone, Stephen V. Tsuang, Ming T. Barbara, Cornblatt
Abstract	Siblings and offspring of persons with schizophrenia carry elevated genetic risk for the illness and manifest attentional and memory impairments. Because less is known about other neuropsychological functions and their specificity in adolescents, we conducted a genetic high-risk (HR) study of schizophrenia (HR-SCZ) and affective psychosis (HR-AFF). Participants (ages 12–25) were from the Harvard Adolescent High-Risk and Hillside Family studies, including 73 HR-SCZ, 18 HR-AFF, and 84 community controls (CCs) recruited in metropolitan Boston and New York. Groups were compared on overall neurocognitive functioning, 6 domains, and 13 test scores, controlling for age, parental education, and correlated data within families. The HR-SCZ group was significantly impaired overall, while the HR-AFF group demonstrated a trend toward overall impairment. HR-SCZ subjects showed significantly lower Verbal Ability (d = .73) and Executive Functioning/Working Memory (d = .47) than CCs. HR-AFF subjects showed reduced Verbal Ability (d = .64) compared to CCs. Excluding 12 CCs with a parental history of depression (without psychosis) led to larger differences between HR and CC groups across domains. Moreover, HR-SCZ and CC group differences in Verbal Memory (d = .39) and Visual-Spatial (d = .34) became statistically significant. There were no significant differences between HR-SCZ and HR-AFF groups. Data support a modest neuropsychological deficit in persons at genetic HR for psychosis, with a broader range of deficits in HR-SCZ. Future work should assess the relationship of neurocognition to adaptive functioning and possible onset of psychosis in HR samples. Ascertainment criteria for controls may markedly influence results and interpretation of group differences.
Related Links	http://dx.doi.org/10.1093/schbul/sbj078
Starting Page	507
File Format	PDF
ISSN	17451701
e-ISSN	17451701
Journal	Schizophrenia Bulletin
Issue Number	3
Volume Number	32
Language	English
Publisher	Oxford University Press
Publisher Date	2006-07-01
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Schizophrenia Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Psychiatry and Mental Health

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