NDLI: Na,K-ATPase signal transduction triggers CREB activation and dendritic growth

Content Provider	PubMed Central
Author	Luc, Desfrere Karlsson, Marie Hiyoshi, Hiromi Seth, Malmersjö Nanou, Evanthia Estrada, Manuel Miyakawa, Ayako Lagercrantz, Hugo El, Manira Abdeljabbar Lal, Mark Per, Uhlén
Abstract	Dendritic growth is pivotal in the neurogenesis of cortical neurons. The sodium pump, or Na,K-ATPase, is an evolutionarily conserved protein that, in addition to its central role in establishing the electrochemical gradient, has recently been reported to function as a receptor and signaling mediator. Although a large body of evidence points toward a dual function for the Na,K-ATPase, few biological implications of this signaling pathway have been described. Here we report that Na,K-ATPase signal transduction triggers dendritic growth as well as a transcriptional program dependent on cAMP response element binding protein (CREB) and cAMP response element (CRE)-mediated gene expression, primarily regulated via Ca2+/calmodulin-dependent protein (CaM) kinases. The signaling cascade mediating dendritic arbor growth also involves intracellular Ca2+ oscillations and sustained phosphorylation of mitogen-activated protein (MAP) kinases. Thus, our results suggest a novel role for the Na,K-ATPase as a modulator of dendritic growth in developing neurons.
Related Links	http://dx.doi.org/10.1073/pnas.0809253106
Ending Page	2217
Page Count	6
Starting Page	2212
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	106
Language	English
Publisher	National Academy of Sciences
Publisher Date	2009-02-17
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Correction for Desfrere et al., Na,K-ATPase signal transduction triggers CREB activation and dendritic growth

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