NDLI: Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo

Content Provider	PubMed Central
Author	Tewalt, Eric F. Maynard, Jason C. Walters, Julie Jo Schell, Amanda M. Berwin, Brent L. Norbury, Christopher C. Nicchitta, Christopher V.
Copyright Year	2008
Abstract	CD8+ T cells (TCD8+) differentiate into effector cells following recognition of specific peptide–major histocompatibility complex (MHC) class I complexes (pMHC-I) on the surface of professional APCs (pAPCs), such as dendritic cells. Antigenic pMHC-I can be generated from two spatially distinct sources. The direct presentation pathway involves generation of peptide from protein substrate synthesized within the cell that is presenting the pMHC-I. Alternatively, the cross presentation pathway involves presentation of antigen that is not synthesized within the presenting cell, but is derived from exogenous proteins synthesized within other donor cells. The mechanisms by which cross presentation of exogenous antigens occur in vivo remain controversial. The C-type lectin scavenger receptor A (SR-A) has been implicated in a number of potential cross presentation pathways, including the presentation of peptide bound to heat shock proteins, such as glycoprotein 96 (gp96), and the transfer of pMHC-I from a donor cell to the pAPC. We demonstrate here that initiation of TCD8+ responses is normal in mice lacking SR-A, and that the redundancy of ligand binding exhibited by the SR family is likely to be an important mechanism that ensures cross presentation in vivo. These observations emphasize the requirement to target multiple receptors and antigen-processing pathways during the rational design of vaccines aimed at eliciting protective TCD8+.
Related Links	http://dx.doi.org/10.1111/j.1365-2567.2008.02861.x
Ending Page	491
Page Count	12
Starting Page	480
File Format	PDF
ISSN	00192805
e-ISSN	13652567
Journal	Immunology
Issue Number	4
Volume Number	125
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2008-12-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Immunology Immunology and Allergy Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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