NDLI: The Genome of Burkholderia cenocepacia J2315, an Epidemic Pathogen of Cystic Fibrosis Patients ▿ †

Content Provider	PubMed Central
Author	Holden, Matthew T. G. Seth Smith, Helena M. B. Crossman, Lisa C. Sebaihia, Md Bentley, Stephen D. Cerdeño-tárraga, Ana M. Thomson, Nicholas R. Bason, Nathalie Quail, Michael A. Sharp, Sarah Cherevach, Inna Churcher, Carol Goodhead, Ian Hauser, Heidi Holroyd, Nancy Mungall, Karen Scott, Paul Walker, Danielle White, Brian Rose, Helen Iversen, Pernille Dalila, Mil-homens Rocha, Eduardo P. C. Fialho, Arsenio M. Baldwin, Adam Dowson, Christopher Barrell, Bart G. Govan, John R. Vandamme, Peter Hart, C. Anthony Eshwar, Mahenthiralingam Parkhill, Julian
Abstract	Bacterial infections of the lungs of cystic fibrosis (CF) patients cause major complications in the treatment of this common genetic disease. Burkholderia cenocepacia infection is particularly problematic since this organism has high levels of antibiotic resistance, making it difficult to eradicate; the resulting chronic infections are associated with severe declines in lung function and increased mortality rates. B. cenocepacia strain J2315 was isolated from a CF patient and is a member of the epidemic ET12 lineage that originated in Canada or the United Kingdom and spread to Europe. The 8.06-Mb genome of this highly transmissible pathogen comprises three circular chromosomes and a plasmid and encodes a broad array of functions typical of this metabolically versatile genus, as well as numerous virulence and drug resistance functions. Although B. cenocepacia strains can be isolated from soil and can be pathogenic to both plants and man, J2315 is representative of a lineage of B. cenocepacia rarely isolated from the environment and which spreads between CF patients. Comparative analysis revealed that ca. 21% of the genome is unique in comparison to other strains of B. cenocepacia, highlighting the genomic plasticity of this species. Pseudogenes in virulence determinants suggest that the pathogenic response of J2315 may have been recently selected to promote persistence in the CF lung. The J2315 genome contains evidence that its unique and highly adapted genetic content has played a significant role in its success as an epidemic CF pathogen.
Related Links	http://dx.doi.org/10.1128/jb.01230-08
Ending Page	277
Page Count	17
Starting Page	261
File Format	PDF
ISSN	00219193
e-ISSN	10985530
Journal	Journal of Bacteriology
Issue Number	1
Volume Number	191
Language	English
Publisher	American Society for Microbiology (ASM)
Publisher Date	2009-01-01
Access Restriction	Open
Rights Holder	American Society for Microbiology (ASM)
Subject Keyword	Molecular Biology Microbiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Microbiology

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The Genome of Burkholderia cenocepacia J2315, an Epidemic Pathogen of Cystic Fibrosis Patients

Improved Electrotransformation and Decreased Antibiotic Resistance of the Cystic Fibrosis Pathogen Burkholderia cenocepacia Strain J2315

Reconstitution of O-Specific Lipopolysaccharide Expression in Burkholderia cenocepacia Strain J2315, Which Is Associated with Transmissible Infections in Patients with Cystic Fibrosis†

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