NDLI: Calcium signalling during neural induction in Xenopus laevis embryos

Content Provider	PubMed Central
Author	Moreau, Marc Isabelle, Néant Webb, Sarah E. Miller, Andrew L. Leclerc, Catherine
Copyright Year	2008
Abstract	In Xenopus, experiments performed with isolated ectoderm suggest that neural determination is a ‘by default’ mechanism, which occurs when bone morphogenetic proteins (BMPs) are antagonized by extracellular antagonists, BMP being responsible for the determination of epidermis. However, Ca2+ imaging of intact Xenopus embryos reveals patterns of Ca2+ transients which are generated via the activation of dihydropyridine-sensitive Ca2+ channels in the dorsal ectoderm but not in the ventral ectoderm. These increases in the concentration of intracellular Ca2+([Ca2+]i) appear to be necessary and sufficient to orient the ectodermal cells towards a neural fate as increasing the [Ca2+]i artificially results in neuralization of the ectoderm. We constructed a subtractive cDNA library between untreated and caffeine-treated ectoderms (to increase [Ca2+]i) and then identified early Ca2+-sensitive target genes expressed in the neural territories. One of these genes, an arginine methyltransferase, controls the expression of the early proneural gene, Zic3. Here, we discuss the evidence for the existence of an alternative model to the ‘by default’ mechanism, where Ca2+ plays a central regulatory role in the expression of Zic3, an early proneural gene, and in epidermal determination which only occurs when the Ca2+-dependent signalling pathways are inactive.
Related Links	http://dx.doi.org/10.1098/rstb.2007.2254
Ending Page	1375
Page Count	5
Starting Page	1371
File Format	PDF
ISSN	09628436
e-ISSN	14712970
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Issue Number	1495
Volume Number	363
Language	English
Publisher	The Royal Society
Publisher Date	2008-04-12
Access Restriction	Open
Rights Holder	The Royal Society
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology Agricultural and Biological Sciences

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Imaging patterns of calcium transients during neural induction in Xenopus laevis embryos

Changes in Oscillatory Dynamics in the Cell Cycle of Early Xenopus laevis Embryos

Calcium signalling in early embryos

Calcium signalling during the cleavage period of zebrafish development

sox4 And sox11 Function during Xenopus laevis Eye Development

Circadian Genes Are Expressed during Early Development in Xenopus laevis

Neural Induction without Mesoderm in Xenopus

Spatial characteristics to calcium signalling; the calcium wave as a basic unit in plant cell calcium signalling

The Expression of TALEN before Fertilization Provides a Rapid Knock-Out Phenotype in Xenopus laevis Founder Embryos

Calcium signalling during neural induction in Xenopus laevis embryos

Similar Documents

Imaging patterns of calcium transients during neural induction in Xenopus laevis embryos

Changes in Oscillatory Dynamics in the Cell Cycle of Early Xenopus laevis Embryos

Calcium signalling in early embryos

Calcium signalling during the cleavage period of zebrafish development

sox4 And sox11 Function during Xenopus laevis Eye Development

Circadian Genes Are Expressed during Early Development in Xenopus laevis

Neural Induction without Mesoderm in Xenopus

Spatial characteristics to calcium signalling; the calcium wave as a basic unit in plant cell calcium signalling

The Expression of TALEN before Fertilization Provides a Rapid Knock-Out Phenotype in Xenopus laevis Founder Embryos

Calcium signalling during neural induction in Xenopus laevis embryos