NDLI: Age-related appearance of a CMV-specific high-avidity CD8+ T cell clonotype which does not occur in young adults

Please wait, while we are loading the content...

Aged B lymphocytes retain their ability to express surface markers but are dysfunctional in their proliferative capability during early activation events

The association of elevated reactive oxygen species levels from neutrophils with low-grade inflammation in the elderly

The metal ion theory of ageing: dietary target hazard quotients beyond radicals

Alzheimer's disease: new diagnostic and therapeutic tools

Smoking, health and ageing

Year: 2007, Volume: 4

Year: 2005, Volume: 2

Year: 2004, Volume: 1

Age-related appearance of a CMV-specific high-avidity CD8+ T cell clonotype which does not occur in young adults

Content Provider	PubMed Central
Author	Angelika, Schwanninger Weinberger, Birgit Weiskopf, Daniela Dietmar, Herndler-brandstetter Reitinger, Stephan Gassner, Christoph Schennach, Harald Parson, Walther Reinhard, Würzner Beatrix, Grubeck-loebenstein
Copyright Year	2008
Abstract	Old age is associated with characteristic changes of the immune system contributing to higher incidence and severity of many infectious diseases. Particularly within the T cell compartment latent infection with human Cytomegalovirus (CMV) is contributing to and accelerating immunosenescence. However, latent CMV infection and reactivation usually does not cause overt symptoms in immunocompetent elderly persons indicating immunological control of disease. Little is still known about the clonal composition of CMV-specific T cell responses in donors of different age. We therefore analyzed CD8+ T cells specific for an immunodominant pp65-derived nonamer-peptide (NLVPMVATV; CMVNLV) in different age-groups. Independent of donor age CMVNLV-specific CD8+ T cells preferentially use the V beta family 8. This family has monoclonal expansions in the majority of donors after stimulation of CD8+ T cells with the peptide. By sequencing the CDR3 region of the T cell receptor we demonstrated that CMVNLV-specific, BV8+ CD8+ T cells share the conserved CDR3-sequence motif SANYGYT in donors of all age groups. Interestingly, a second conserved clonotype with the CDR3-sequence motif SVNEAF appears in middle-aged and elderly donors. This clonotype is absent in young individuals. The age-related clonotype SVNEAF binds to the pMHC-complex with higher avidity than the clonotype SANYGYT, which is predominant in young adults. The dominance of this high avidity clonotype may explain the lack of overt CMV-disease in old age.
Related Links	http://dx.doi.org/10.1186/1742-4933-5-14
Starting Page	14
File Format	PDF
ISSN	17424933
e-ISSN	17424933
Journal	Immunity & Ageing : I & A
Volume Number	5
Language	English
Publisher	BioMed Central
Publisher Date	2008-01-01
Access Restriction	Open
Rights Holder	BioMed Central
Subject Keyword	Immunology Ageing Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Aging Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Age-related appearance of a CMV-specific high-avidity CD8+ T cell clonotype which does not occur in young adults

Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors

Multifunctional cytomegalovirus (CMV)-specific CD8+ T cells are not restricted by telomere-related senescence in young or old adults

Age Associated Increase of Low Avidity CMV-Specific CD8+ T Cells That Re-Express CD45RA

Impaired specific CD8 T cell response with aging is not due to decreased expression of CD90 on TCR transgenic T cells

Relationship between cytomegalovirus (CMV) IgG serology, detectable CMV DNA in peripheral monocytes, and CMV pp65495–503-specific CD8+ T cells in older adults

Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T Cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV-Specific T Cells

Age-related decrease of miRNA-92a levels in human CD8+ T-cells correlates with a reduction of naïve T lymphocytes

Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors

Age-related appearance of a CMV-specific high-avidity CD8+ T cell clonotype which does not occur in young adults

Similar Documents

Age-related appearance of a CMV-specific high-avidity CD8+ T cell clonotype which does not occur in young adults

Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors

Multifunctional cytomegalovirus (CMV)-specific CD8+ T cells are not restricted by telomere-related senescence in young or old adults

Age Associated Increase of Low Avidity CMV-Specific CD8+ T Cells That Re-Express CD45RA

Impaired specific CD8 T cell response with aging is not due to decreased expression of CD90 on TCR transgenic T cells

Relationship between cytomegalovirus (CMV) IgG serology, detectable CMV DNA in peripheral monocytes, and CMV pp65495–503-specific CD8+ T cells in older adults

Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T Cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV-Specific T Cells

Age-related decrease of miRNA-92a levels in human CD8+ T-cells correlates with a reduction of naïve T lymphocytes

Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors

Age-related appearance of a CMV-specific high-avidity CD8+ T cell clonotype which does not occur in young adults