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| Content Provider | PubMed Central |
|---|---|
| Author | Kirwan, C. B. Wixted, John T. Squire, L. R. |
| Abstract | FMRI studies of recognition memory have often been interpreted to mean that the hippocampus supports recollection and that the adjacent perirhinal cortex supports familiarity. Other work suggests that these studies have confounded recollection and familiarity with strong and weak memories. In a source memory study, we used two novel approaches to data analysis that allowed item memory strength and source memory strength to be assessed independently. First, we identified regions in both hippocampus and perirhinal cortex where activity varied as a function of subsequent item memory strength while source memory strength was held constant at chance levels. Second, we identified regions in prefrontal cortex where activity varied as a function of subsequent source memory strength while item memory strength was held constant. These findings suggest that activity in the medial temporal lobe is predictive of subsequent memory strength, whereas activity in prefrontal cortex is predictive of subsequent recollection. |
| Related Links | http://dx.doi.org/10.1523/JNEUROSCI.3456-08.2008 |
| Starting Page | 10541 |
| File Format | |
| ISSN | 15292401 |
| e-ISSN | 15292401 |
| Journal | The Journal of neuroscience : the official journal of the Society for Neuroscience |
| Issue Number | 42 |
| Volume Number | 28 |
| Language | English |
| Publisher Date | 2008-10-15 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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