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| Content Provider | PubMed Central |
|---|---|
| Author | Girroir, Elizabeth E. Hollingshead, Holly E. He, Pengfei Zhu, Bokai Perdew, Gary H. Peters, Jeffrey M. |
| Abstract | The expression patterns of PPARβ/δ have been described, but the majority of these data are based on mRNA data. To date, there are no reports that have quantitatively examined the expression of PPARβ/δ protein in mouse tissues. In the present study, a highly specific PPARβ/δ antibody was developed, characterized and used to examine tissue expression patterns of PPARβ/δ. As compared to commercially available anti-PPARβ/δ antibodies, one of six polyclonal anti-PPARβ/δ antibodies developed was significantly more effective for immunoprecipitation of in vitro translated PPARβ/δ. This antibody was used for quantitative western blot analysis using radioactive detection methods. Expression of PPARβ/δ was highest in colon, small intestine, liver and keratinocytes as compared to other tissues including heart, spleen, skeletal muscle, lung, brain and thymus. Interestingly, PPARβ/δ expression was localized in the nucleus and RXRα can be co-immunoprecipitated with nuclear PPARβ/δ. Results from these studies demonstrate that PPARβ/δ expression is highest in intestinal epithelium, liver and keratinocytes, consistent with significant biological roles in these tissues. |
| Related Links | http://dx.doi.org/10.1016/j.bbrc.2008.04.086 |
| Ending Page | 461 |
| Page Count | 6 |
| Starting Page | 456 |
| File Format | |
| ISSN | 0006291X |
| e-ISSN | 10902104 |
| Journal | Biochemical and biophysical research communications |
| Issue Number | 3 |
| Volume Number | 371 |
| Language | English |
| Publisher Date | 2008-07-01 |
| Access Restriction | Open |
| Subject Keyword | Biophysics Cell Biology Biochemistry Molecular Biology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Biochemistry Biophysics |
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