NDLI: A live attenuated cold adapted influenza A H7N3 virus vaccine provides protection against homologous and heterologous H7 viruses in mice and ferrets

Content Provider	PubMed Central
Author	Joseph, Tomy Mcauliffe, Josephine Lu, Bin Vogel, Leatrice Swayne, David Jin, Hong Kemble, George Subbarao, Kanta
Abstract	The appearance of human infections caused by avian influenza A H7 subtype viruses underscore their pandemic potential and the need to develop vaccines to protect humans from viruses of this subtype. A live attenuated H7N3 virus vaccine was generated by reverse genetics using the HA and NA genes of a low pathogenicity A/chicken/BC/CN-6/04 (H7N3) virus and the six internal protein genes of the cold-adapted A/Ann Arbor/6/60 ca (H2N2) virus. The reassortant H7N3 BC 04 ca vaccine virus was temperature sensitive and showed attenuation in mice and ferrets. Intranasal immunization with one dose of the vaccine protected mice and ferrets when challenged with homologous and heterologous H7 viruses. The reassortant H7N3 BC 04 ca vaccine virus showed comparable levels of attenuation, immunogenicity and efficacy in mice and ferret models. The safety, immunogenicity, and efficacy of this vaccine in mice and ferrets support the evaluation of this vaccine in clinical trials.
Related Links	http://dx.doi.org/10.1016/j.virol.2008.05.021
Ending Page	132
Page Count	10
Starting Page	123
File Format	PDF
ISSN	00426822
e-ISSN	10960341
Journal	Virology
Issue Number	1
Volume Number	378
Language	English
Publisher Date	2008-08-01
Access Restriction	Open
Subject Keyword	Virology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology

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A live attenuated cold adapted influenza A H7N3 virus vaccine provides protection against homologous and heterologous H7 viruses in mice and ferrets