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| Content Provider | PubMed Central |
|---|---|
| Author | Demuth, Ilja Bradshaw, Paul S. Lindner, Anika Anders, Marco Heinrich, Stefanie Kallenbach, Julia Schmelz, Karin Digweed, Martin Meyn, M. Stephen Concannon, Patrick |
| Abstract | Human SNM1B/Apollo is involved in the cellular response to DNA-damage, however, its precise role is unknown. Recent reports have implicated hSNM1B in the protection of telomeres. We have found hSNM1B to interact with TRF2, a protein which functions in telomere protection and in an early response to ionizing radiation. Here we show that endogenous hSNM1B forms foci which colocalize at telomeres with TRF1 and TRF2. However, we observed that additional hSNM1B foci could be induced upon exposure to ionizing radiation (IR). In live-cell-imaging experiments, hSNM1B localized to photoinduced double-strand breaks (DSBs) within 10s post-induction. Further supporting a role for hSNM1B in the early stages of the cellular response to DSBs, we observed that autophosphorylation of ATM, as well as the phosphorylation of ATM target proteins in response to IR, was attenuated in cells depleted of hSNM1B. These observations suggest an important role for hSNM1B in the response to IR damage, a role that may be, in part, upstream of the central player in maintenance of genome integrity, ATM. |
| Related Links | http://dx.doi.org/10.1016/j.dnarep.2008.03.020 |
| Ending Page | 1201 |
| Page Count | 10 |
| Starting Page | 1192 |
| File Format | |
| ISSN | 15687864 |
| Journal | DNA repair |
| Issue Number | 8 |
| Volume Number | 7 |
| Language | English |
| Publisher Date | 2008-08-01 |
| Access Restriction | Open |
| Subject Keyword | Cell Biology Biochemistry Molecular Biology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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