NDLI: Separate Peripheral Pathways for Pruritus in Man

Content Provider	PubMed Central
Author	Namer, Barbara Carr, Richard Johanek, Lisa M. Schmelz, Martin Handwerker, Hermann O. Matthias, Ringkamp
Abstract	Recent findings suggest that itch produced by intradermal insertion of cowhage spicules in human is histamine independent. Neuronal mechanisms underlying nonhistaminergic itch are poorly understood. To investigate which nerve fibers mediate cowhage induced itch in man, action potentials were recorded from cutaneous C-fibers of the peroneal nerve in healthy volunteers using microneurography. Mechano-responsive and -insensitive C-nociceptors were tested for their responsiveness to cowhage spicules, histamine, and capsaicin. Cowhage spicules induced itching and activated all tested mechano-responsive C-units (24/24, but no mechano-insensitive C-fibers (0/17). Histamine also induced itch, but in contrast to cowhage, it caused lasting activation only in mechano-insensitive units (8/12). In mechano-responsive C-units, histamine caused no or only short and weak responses unrelated to the time course of itching. Capsaicin injections activated four of six mechano-responsive fibers and three of four mechano-insensitive C-fibers. Cowhage and histamine activate distinctly different nonoverlapping populations of C-fibers while inducing similar sensations of itch. We hypothesize that cowhage activates a pathway for itch that originates peripherally from superficial mechano-responsive (polymodal) C-fibers and perhaps other afferent units. It is distinct from the pathway for histamine-mediated pruritus and does not involve the histamine-sensitive mechano-insensitive fibers.
Related Links	http://dx.doi.org/10.1152/jn.90482.2008
Ending Page	2069
Page Count	8
Starting Page	2062
File Format	PDF
ISSN	00223077
e-ISSN	15221598
Journal	Journal of Neurophysiology
Issue Number	4
Volume Number	100
Language	English
Publisher	American Physiological Society
Publisher Date	2008-08-01
Access Restriction	Open
Rights Holder	American Physiological Society
Subject Keyword	Physiology Neuroscience(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Physiology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Serotonin Activates Overall Feeding by Activating Two Separate Neural Pathways in Caenorhabditis elegans

Concurrent brain responses to separate auditory and visual targets

Separate Ion Pathways in a Cl−/H+ Exchanger

Utricular afferents: morphology of peripheral terminals

Intestinal Transport of Cystine and Cysteine in Man: Evidence for Separate Mechanisms *

Neural Substrate of Modified and Unmodified Pathways for Learning in Monkey Vestibuloocular Reflex

Disinhibitory recruitment of NMDA receptor pathways in retina

Src and Ras are involved in separate pathways in epithelial cell scattering.

Toll-like Receptor-7 Mediates Pruritus

Separate Peripheral Pathways for Pruritus in Man

Similar Documents

Serotonin Activates Overall Feeding by Activating Two Separate Neural Pathways in Caenorhabditis elegans

Concurrent brain responses to separate auditory and visual targets

Separate Ion Pathways in a Cl−/H+ Exchanger

Utricular afferents: morphology of peripheral terminals

Intestinal Transport of Cystine and Cysteine in Man: Evidence for Separate Mechanisms *

Neural Substrate of Modified and Unmodified Pathways for Learning in Monkey Vestibuloocular Reflex

Disinhibitory recruitment of NMDA receptor pathways in retina

Src and Ras are involved in separate pathways in epithelial cell scattering.

Toll-like Receptor-7 Mediates Pruritus

Separate Peripheral Pathways for Pruritus in Man