WebSite Logo
  • Content
  • Similar Resources
  • Metadata
  • Cite This
  • Language
    অসমীয়া বাংলা भोजपुरी डोगरी English ગુજરાતી हिंदी ಕನ್ನಡ
    Khasi कोंकणी मैथिली മലയാളം ꯃꯤꯇꯩ ꯂꯣꯟ मराठी Mizo नेपाली
    ଓଡ଼ିଆ ਪੰਜਾਬੀ संस्कृत ᱥᱟᱱᱛᱟᱲᱤ सिन्धी தமிழ் తెలుగు اردو
  • Log-in
  • Fullscreen
Log-in
Do not have an account? Register Now
Forgot your password? Account recovery
  1. Tuberculosis (Edinburgh, Scotland)
  2. Year: 2008, Volume: 88
  3. Year: 2008, Volume: 88, Issue: 4
  4. Disseminated disease severity as a measure of virulence of Mycobacterium tuberculosis in the guinea pig model
Loading...

Please wait, while we are loading the content...

Year: 2016, Volume: 98
Year: 2016, Volume: 96
Year: 2015, Volume: 95
Year: 2014, Volume: 94
Year: 2013, Volume: 93
Year: 2012, Volume: 92
Year: 2011, Volume: 91S1
Year: 2011, Volume: 91
Year: 2010, Volume: 90
Year: 2009, Volume: 89
Year: 2008, Volume: 88
Year: 2008, Volume: 88, Issue: 6
Year: 2008, Volume: 88, Issue: 5
Year: 2008, Volume: 88, Issue: 4
Mycobacterium tuberculosis PE_PGRS16 and PE_PGRS26 Genetic Polymorphism among Clinical Isolates
Disseminated disease severity as a measure of virulence of Mycobacterium tuberculosis in the guinea pig model
Meeting Report: NIH Workshop on the Tuberculosis Immune Epitope Database
Year: 2008, Volume: 88, Issue: 3
Year: 2008, Volume: 88, Issue: 1
Year: 2007, Volume: 87
Year: 2006, Volume: 86
Year: 2004, Volume: 84

Similar Documents

...
Disseminated disease severity as a measure of virulence of Mycobacterium tuberculosis in the guinea pig model

Article

...
Guinea Pig Model of Mycobacterium tuberculosis Dormant Infection

Article

...
HspX Vaccination and Role in Virulence in the Guinea Pig Model of Tuberculosis

Article

...
Whole genome response in guinea pigs infected with the high virulence strain Mycobacterium tuberculosis TT372

Article

...
Guinea pig neutrophil-macrophage interactions during infection with Mycobacterium tuberculosis

Article

...
Immunopathogenesis of Pulmonary Granulomas in the Guinea Pig after Infection with Mycobacterium tuberculosis

Article

...
Sulfolipid Deficiency Does Not Affect the Virulence of Mycobacterium tuberculosis H37Rv in Mice and Guinea Pigs

Article

...
Assessment of vaccine testing at three laboratories using the guinea pig model of tuberculosis

Article

...
Critical Role of LuxS in the Virulence of Campylobacter jejuni in a Guinea Pig Model of Abortion

Article

Disseminated disease severity as a measure of virulence of Mycobacterium tuberculosis in the guinea pig model

Content Provider PubMed Central
Author Palanisamy, Gopinath S. Smith, Erin E. Shanley, Crystal A. Ordway, Diane J. Orme, Ian M. Basaraba, Randall J.
Abstract Virulence is the measure of pathogenicity of a microorganism as determined by its ability to invade host tissues and to produce severe disease. In the low-dose aerosol guinea pig model the virulence of multiple strains of Mycobacterium tuberculosis was determined by measuring time of survival, bacterial loads in target organs, and the severity of pulmonary and extra-pulmonary lesions. Erdman K01, CSU93/CDC1551 and HN878 had shorter survival times compared to the common laboratory strain H37Rv. After thirty days of the infection bacilli had disseminated from the lungs resulting in microscopically visible lesions in peribronchial lymph nodes, peripancreatic lymph nodes, spleen, liver, pancreas, adrenal and heart. The extent of the lesion necrosis paralleled virulence when survival times were used as a measure as Erdman K01 and the two clinical isolates caused more necrosis and resulted in sooner death in infected animals than the H37Rv. The extent of extra-pulmonary lesion necrosis was a better predictor of virulence than the number of viable bacilli in the tissue. Overall, this study emphasizes the point that extra-pulmonary disease is a prominent feature of the guinea pig model and dissemination to organs not normally assayed such as the heart and adrenal glands should be taken into account in the assessment of the disease process.
Related Links http://dx.doi.org/10.1016/j.tube.2007.12.003
Ending Page 306
Page Count 12
Starting Page 295
File Format PDF
ISSN 14729792
e-ISSN 1873281X
Journal Tuberculosis (Edinburgh, Scotland)
Issue Number 4
Volume Number 88
Language English
Publisher Date 2008-07-01
Access Restriction Open
Subject Keyword Immunology Microbiology (medical) Microbiology Infectious Diseases Research in Higher Education
Content Type Text
Resource Type Article
Subject Infectious Diseases Immunology Microbiology Microbiology (medical)
  • About
  • Disclaimer
  • Feedback
  • Sponsor
  • Contact
About National Digital Library of India (NDLI)
NDLI logo

National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.

Learn more about this project from here.

Disclaimer

NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.

Feedback

Sponsor

Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.

Contact National Digital Library of India
Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302
See location in the Map
03222 282435
Mail: support@ndl.gov.in
Sl. Authority Responsibilities Communication Details
1 Ministry of Education (GoI),
Department of Higher Education
Sanctioning Authority https://www.education.gov.in/ict-initiatives
2 Indian Institute of Technology Kharagpur Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project https://www.iitkgp.ac.in
3 National Digital Library of India Office, Indian Institute of Technology Kharagpur The administrative and infrastructural headquarters of the project Dr. B. Sutradhar  bsutra@ndl.gov.in
4 Project PI / Joint PI Principal Investigator and Joint Principal Investigators of the project Dr. B. Sutradhar  bsutra@ndl.gov.in
Prof. Saswat Chakrabarti  will be added soon
5 Website/Portal (Helpdesk) Queries regarding NDLI and its services support@ndl.gov.in
6 Contents and Copyright Issues Queries related to content curation and copyright issues content@ndl.gov.in
7 National Digital Library of India Club (NDLI Club) Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach clubsupport@ndl.gov.in
8 Digital Preservation Centre (DPC) Assistance with digitizing and archiving copyright-free printed books dpc@ndl.gov.in
9 IDR Setup or Support Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops idr@ndl.gov.in
Cite this Content
Loading...