NDLI: Age-specific incidence of cancer: Phases, transitions, and biological implications

Content Provider	PubMed Central
Author	Meza, Rafael Jeon, Jihyoun Moolgavkar, Suresh H. Georg, Luebeck E.
Abstract	The observation that the age-specific incidence curve of many carcinomas is approximately linear on a double logarithmic plot has led to much speculation regarding the number and nature of the critical events involved in carcinogenesis. By a consideration of colorectal and pancreatic cancers in the Surveillance Epidemiology and End Results (SEER) registry we show that the log-log model provides a poor description of the data, and that a much better description is provided by a multistage model that predicts two basic phases in the age-specific incidence curves, a first exponential phase until the age of ≈60 followed by a linear phase after that age. These two phases in the incidence curve reflect two phases in the process of carcinogenesis. Paradoxically, the early-exponential phase reflects events between the formation (initiation) of premalignant clones in a tissue and the clinical detection of a malignant tumor, whereas the linear phase reflects events leading to initiated cells that give rise to premalignant lesions because of abrogated growth/differentiation control. This model is consistent with Knudson's idea that renewal tissue, such as the colon, is converted into growing tissue before malignant transformation. The linear phase of the age-specific incidence curve represents this conversion, which is the result of recessive inactivation of a gatekeeper gene, such as the APC gene in the colon and the CDKN2A gene in the pancreas.
Related Links	http://dx.doi.org/10.1073/pnas.0801151105
Ending Page	16289
Page Count	6
Starting Page	16284
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	42
Volume Number	105
Language	English
Publisher	National Academy of Sciences
Publisher Date	2008-10-21
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Parallel Routes of Human Carcinoma Development: Implications of the Age-Specific Incidence Data

Age-specific incidence of inherited versus sporadic cancers: A test of the multistage theory of carcinogenesis

Age incidence curves for cancer.

Age-Specific Incidence of Breast Cancer Subtypes: Understanding the Black–White Crossover

Age-Specific Trends in Incidence of Noncardia Gastric Cancer in US Adults

Similarities in the Age-Specific Incidence of Colon and Testicular Cancers

Age-specific incidence rates for cytogenetically-defined subtypes of acute myeloid leukaemia

International testicular cancer incidence trends: generational transitions in 38 countries 1900–1990

Ovarian cancer histology-specific incidence trends in Canada 1969–1993: age-period-cohort analyses

Age-specific incidence of cancer: Phases, transitions, and biological implications

Similar Documents

Parallel Routes of Human Carcinoma Development: Implications of the Age-Specific Incidence Data

Age-specific incidence of inherited versus sporadic cancers: A test of the multistage theory of carcinogenesis

Age incidence curves for cancer.

Age-Specific Incidence of Breast Cancer Subtypes: Understanding the Black–White Crossover

Age-Specific Trends in Incidence of Noncardia Gastric Cancer in US Adults

Similarities in the Age-Specific Incidence of Colon and Testicular Cancers

Age-specific incidence rates for cytogenetically-defined subtypes of acute myeloid leukaemia

International testicular cancer incidence trends: generational transitions in 38 countries 1900–1990

Ovarian cancer histology-specific incidence trends in Canada 1969–1993: age-period-cohort analyses

Age-specific incidence of cancer: Phases, transitions, and biological implications