NDLI: Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification

Content Provider	PubMed Central
Author	Carmine, Settembre Emilio, Arteaga-solis Mckee, Marc D. Pablo, Raquel De Al, Awqati Qais Ballabio, Andrea Karsenty, Gerard
Copyright Year	2008
Abstract	Cartilage extracellular matrix (ECM) contains large amounts of proteoglycans made of a protein core decorated by highly sulfated sugar chains, the glycosaminoglycans (GAGs). GAGs desulfation, a necessary step for their degradation, is exerted by sulfatases that are activated by another enzyme, Sulfatase-Modifying Factor 1 (SUMF1), whose inactivation in humans leads to severe skeletal abnormalities. We show here that despite being expressed in both osteoblasts and chondrocytes Sumf1 does not affect osteoblast differentiation. Conversely, in chondrocytes it favors ECM production and autophagy and promotes proliferation and differentiation by limiting FGF signaling. Thus, proteoglycan desulfation is a critical regulator of chondrogenesis.
Related Links	http://dx.doi.org/10.1101/gad.1711308
Ending Page	2650
Page Count	6
Starting Page	2645
File Format	PDF
ISSN	08909369
e-ISSN	15495477
Journal	Genes & Development
Issue Number	19
Volume Number	22
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2008-10-01
Access Restriction	Open
Rights Holder	Cold Spring Harbor Laboratory Press
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology

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Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification