NDLI: Toll-like receptors: lessons to learn from normal and malignant human B cells

Content Provider	PubMed Central
Author	Chiron, David Isabelle, Bekeredjian-ding Catherine, Pellat-deceunynck Bataille, Régis Jego, Gaëtan
Copyright Year	2008
Abstract	The humoral immune system senses microbes via recognition of specific microbial molecular motifs by Toll-like receptors (TLRs). These encounters promote plasma cell differentiation and antibody production. Recent studies have demonstrated the importance of the TLR system in enhancing antibody-mediated defense against infections and maintaining memory B cells. These results have led the way to the design of vaccines that target B cells by engaging TLRs. In hematologic malignancies, cells often retain B cell–specific receptors and associated functions. Among these, TLRs are currently exploited to target different subclasses of B-cell leukemia, and TLR agonists are currently being evaluated in clinical trials. However, accumulating evidence suggests that endogenous TLR ligands or chronic infections promote tumor growth, thus providing a need for further investigations to decipher the exact function of TLRs in the B-cell lineage and in neoplastic B cells. The aim of this review is to present and discuss the latest advances with regard to the expression and function of TLRs in both healthy and malignant B cells. Special attention will be focused on the growth-promoting effects of TLR ligands on leukemic B cells and their potential clinical impact.
Related Links	http://dx.doi.org/10.1182/blood-2008-02-140673
Ending Page	2213
Page Count	9
Starting Page	2205
File Format	PDF
ISSN	00064971
e-ISSN	15280020
Journal	Blood
Issue Number	6
Volume Number	112
Language	English
Publisher	American Society of Hematology
Publisher Date	2008-09-15
Access Restriction	Open
Rights Holder	American Society of Hematology
Subject Keyword	Immunology Cell Biology Biochemistry Hematology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Hematology Biochemistry Immunology

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