NDLI: Sucrose Exposure in Early Life Alters Adult Motivation and Weight Gain

Content Provider	PubMed Central
Author	Frazier, Cristianne R. M. Mason, Peggy Zhuang, Xiaoxi Beeler, Jeff A.
Editor	Hendricks, Michael
Copyright Year	2008
Abstract	The cause of the current increase in obesity in westernized nations is poorly understood but is frequently attributed to a ‘thrifty genotype,’ an evolutionary predisposition to store calories in times of plenty to protect against future scarcity. In modern, industrialized environments that provide a ready, uninterrupted supply of energy-rich foods at low cost, this genetic predisposition is hypothesized to lead to obesity. Children are also exposed to this ‘obesogenic’ environment; however, whether such early dietary experience has developmental effects and contributes to adult vulnerability to obesity is unknown. Using mice, we tested the hypothesis that dietary experience during childhood and adolescence affects adult obesity risk. We gave mice unlimited or no access to sucrose for a short period post-weaning and measured sucrose-seeking, food consumption, and weight gain in adulthood. Unlimited access to sucrose early in life reduced sucrose-seeking when work was required to obtain it. When high-sugar/high-fat dietary options were made freely-available, however, the sucrose-exposed mice gained more weight than mice without early sucrose exposure. These results suggest that early, unlimited exposure to sucrose reduces motivation to acquire sucrose but promotes weight gain in adulthood when the cost of acquiring palatable, energy dense foods is low. This study demonstrates that early post-weaning experience can modify the expression of a ‘thrifty genotype’ and alter an adult animal's response to its environment, a finding consistent with evidence of pre- and peri-natal programming of adult obesity risk by maternal nutritional status. Our findings suggest the window for developmental effects of diet may extend into childhood, an observation with potentially important implications for both research and public policy in addressing the rising incidence of obesity.
Related Links	http://dx.doi.org/10.1371/journal.pone.0003221
Starting Page	3221
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	9
Volume Number	3
Language	English
Publisher	Public Library of Science
Publisher Date	2008-09-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Sucrose Exposure in Early Life Alters Adult Motivation and Weight Gain

Maternal Obesity during the Preconception and Early Life Periods Alters Pancreatic Development in Early and Adult Life in Male Mouse Offspring

Sugar Overconsumption during Adolescence Selectively Alters Motivation and Reward Function in Adult Rats

Central Melanocortins Regulate the Motivation for Sucrose Reward

Early Gestational Weight Gain Rate and Adverse Pregnancy Outcomes in Korean Women

Trajectories of Childhood Weight Gain: The Relative Importance of Local Environment versus Individual Social and Early Life Factors

Daily Exposure to Dust Alters Innate Immunity

Impact of Birth Weight and Early Infant Weight Gain on Insulin Resistance and Associated Cardiovascular Risk Factors in Adolescence

Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression

Sucrose Exposure in Early Life Alters Adult Motivation and Weight Gain

Similar Documents

Sucrose Exposure in Early Life Alters Adult Motivation and Weight Gain

Maternal Obesity during the Preconception and Early Life Periods Alters Pancreatic Development in Early and Adult Life in Male Mouse Offspring

Sugar Overconsumption during Adolescence Selectively Alters Motivation and Reward Function in Adult Rats

Central Melanocortins Regulate the Motivation for Sucrose Reward

Early Gestational Weight Gain Rate and Adverse Pregnancy Outcomes in Korean Women

Trajectories of Childhood Weight Gain: The Relative Importance of Local Environment versus Individual Social and Early Life Factors

Daily Exposure to Dust Alters Innate Immunity

Impact of Birth Weight and Early Infant Weight Gain on Insulin Resistance and Associated Cardiovascular Risk Factors in Adolescence

Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression

Sucrose Exposure in Early Life Alters Adult Motivation and Weight Gain