NDLI: Retinal waves in mice lacking the β2 subunit of the nicotinic acetylcholine receptor

Content Provider	PubMed Central
Author	Sun, Chao Warland, David K. Ballesteros, Jose M. List, Deborah Van Der Chalupa, Leo M.
Abstract	The structural and functional properties of the visual system are disrupted in mutant animals lacking the β2 subunit of the nicotinic acetylcholine receptor. In particular, eye-specific retinogeniculate projections do not develop normally in these mutants. It is widely thought that the developing retinas of β2−/− mutants do not manifest correlated activity, leading to the notion that retinal waves play an instructional role in the formation of eye-specific retinogeniculate projections. By multielectrode array recordings, we show here that the β2−/− mutants have robust retinal waves during the formation of eye-specific projections. Unlike in WT animals, however, the mutant retinal waves are propagated by gap junctions rather than cholinergic circuitry. These results indicate that lack of retinal waves cannot account for the abnormalities that have been documented in the retinogeniculate pathway of the β2−/− mutants and suggest that other factors must contribute to the deficits in the visual system that have been noted in these animals.
Related Links	http://dx.doi.org/10.1073/pnas.0807178105
Ending Page	13643
Page Count	6
Starting Page	13638
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	36
Volume Number	105
Language	English
Publisher	National Academy of Sciences
Publisher Date	2008-09-09
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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