NDLI: An avian retrovirus expressing chicken pp59c-myc possesses weak transforming activity distinct from v-myc that may be modulated by adjacent normal cell neighbors.

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Molecular anatomy of viral persistence.

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The adenovirus E1A transforming protein activates the proliferating cell nuclear antigen promoter via an activating transcription factor site.

Mutant varicella-zoster virus thymidine kinase: correlation of clinical resistance and enzyme impairment.

The UL20 gene of herpes simplex virus 1 encodes a function necessary for viral egress.

Transactivation of human immunodeficiency virus type 1 long terminal repeats by cell surface tumor necrosis factor alpha.

Differential dependence of herpes simplex virus immediate-early gene expression on de novo-infected cell protein synthesis.

Regulation of polyadenylation of hepatitis delta virus antigenomic RNA.

The ability of large T antigen to complex with p53 is necessary for the increased life span and partial transformation of human cells by simian virus 40.

Mutational analysis of two herpes simplex virus type 1 late promoters.

Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus.

Plasma membrane receptors for ecotropic murine retroviruses require a limiting accessory factor.

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Interaction of a cellular 57-kilodalton protein with the internal translation initiation site of foot-and-mouth disease virus.

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Structural analysis and transcriptional mapping of the Marek's disease virus gene encoding pp38, an antigen associated with transformed cells.

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trans activation of the simian virus 40 late promoter by large T antigen requires binding sites for the cellular transcription factor TEF-1.

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The majority of cells infected with the defective murine AIDS virus belong to the B-cell lineage.

Expression, processing, and assembly of foot-and-mouth disease virus capsid structures in heterologous systems: induction of a neutralizing antibody response in guinea pigs.

Human cytomegalovirus productively infects primary differentiated macrophages.

Human-murine chimeras of ICAM-1 identify amino acid residues critical for rhinovirus and antibody binding.

N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state.

Acquisition of an additional internal cleavage site differentially affects the ability of pseudorabies virus to multiply in different host cells.

Cytotoxic T cells isolated from the central nervous systems of mice infected with Theiler's virus.

An avian retrovirus expressing chicken pp59c-myc possesses weak transforming activity distinct from v-myc that may be modulated by adjacent normal cell neighbors.

Small-form hepatitis B surface antigen is sufficient to help in the assembly of hepatitis delta virus-like particles.

Splice site skipping in polyomavirus late pre-mRNA processing.

Viral persistence during the developmental phase of Coxsackievirus B1-induced murine polymyositis.

Unusual Sp1-GC box interaction in a parvovirus promoter.

Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells.

Characterization of the hepatitis B virus EnhI enhancer and X promoter complex.

Evidence for a chromosomal location of polydnavirus DNA in the ichneumonid parasitoid Hyposoter fugitivus.

Sequence, function, and regulation of the Vmw65 gene of herpes simplex virus type 2.

Rescue of Sindbis virus-specific RNA replication and transcription by using a vaccinia virus recombinant.

Human cytomegalovirus UL36-38 and US3 immediate-early genes: temporally regulated expression of nuclear, cytoplasmic, and polysome-associated transcripts during infection.

Early signal transduction in measles virus-infected lymphocytes is unaltered, but second messengers activate virus replication.

Regulation of herpes simplex virus true late gene expression: sequences downstream from the US11 TATA box inhibit expression from an unreplicated template.

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Translational control of human cytomegalovirus gp48 expression.

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Identification of a novel latency-specific splice donor signal within the herpes simplex virus type 1 2.0-kilobase latency-associated transcript (LAT): translation inhibition of LAT open reading frames by the intron within the 2.0-kilobase LAT.

Analysis of trans-acting response decoy RNA-mediated inhibition of human immunodeficiency virus type 1 transactivation.

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Bovine leukemia virus matrix-associated protein MA(p15): further processing and formation of a specific complex with the dimer of the 5'-terminal genomic RNA fragment.

Role of de novo protein synthesis in target cells recognized by cytotoxic T lymphocytes specific for vesicular stomatitis virus.

Antigenic and immunogenic epitopes shared by human papillomavirus type 16 and bovine, canine, and avian papillomaviruses.

The ability of simian virus 40 large T antigen to immortalize primary mouse embryo fibroblasts cosegregates with its ability to bind to p53.

Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV.

Human T-cell leukemia virus type I Tax induces expression of the Rel-related family of kappa B enhancer-binding proteins: evidence for a pretranslational component of regulation.

Activity of the simian virus 40 early promoter-enhancer in herpes simplex virus type 1 vectors is dependent on its position, the infected cell type, and the presence of Vmw175.

Identification of a putative alphavirus receptor on mouse neural cells.

Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism.

Host range, replicative, and cytopathic properties of human immunodeficiency virus type 1 are determined by very few amino acid changes in tat and gp120.

Circularization of human immunodeficiency virus type 1 DNA in vitro.

Identification and characterization of the herpesvirus saimiri oncoprotein STP-C488.

Transcriptional initiation and postinitiation effects of murine leukemia virus long terminal repeat R-region sequences.

Human cytomegalovirus inhibits human immunodeficiency virus replication in cells productively infected by both viruses.

A conserved coronavirus epitope, critical in virus neutralization, mimicked by internal-image monoclonal anti-idiotypic antibodies.

Immunological elimination of infected cells as the candidate mechanism for tumor protection in polyomavirus-infected mice.

In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model.

Assembly of double-shelled rotaviruslike particles by simultaneous expression of recombinant VP6 and VP7 proteins.

Determination of the origin-specific DNA-binding domain of polyomavirus large T antigen.

Purification and characterization of recombinant equine infectious anemia virus reverse transcriptase.

Chloroquine induces empty capsid formation during poliovirus eclipse.

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Use of a lambda gt11 expression library to localize a neutralizing antibody-binding site in glycoprotein E2 of Sindbis virus.

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The intragenic enhancer of human immunodeficiency virus type 1 contains functional AP-1 binding sites.

Efficient transcription of the Epstein-Barr virus immediate-early BZLF1 and BRLF1 genes requires protein synthesis.

Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16.

Expression of collagenlike sequences by a tumor virus, herpesvirus saimiri.

Induction of human immunodeficiency virus type 1 expression in chronically infected cells is associated primarily with a shift in RNA splicing patterns.

Identification, characterization, and sequence analysis of a cDNA encoding a phosphoprotein of human herpesvirus 6.

Retraction. Moloney murine leukemia virus integration protein produced in yeast binds specifically to viral att sites.

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An avian retrovirus expressing chicken pp59c-myc possesses weak transforming activity distinct from v-myc that may be modulated by adjacent normal cell neighbors.

Content Provider	PubMed Central
Author	Filardo, E. J. Humphries, E. H.
Abstract	We demonstrate that EF168, an avian retrovirus that expresses the chicken pp59c-myc proto-oncogene, transforms quail embryo fibroblasts in vitro. An EF168-transformed quail clone, EF168-28, containing a single provirus, synthesizes several hundred copies of c-myc RNA and expresses elevated levels of the pp59c-myc gene product. The EF168 provirus in EF168-28 was isolated as a molecular clone, and the nucleotide sequence of its c-myc allele was confirmed as identical to that of exons 2 and 3 of the chicken c-myc proto-oncogene. Extended infection of quail embryo fibroblast cultures with EF168 induced a number of in vitro transformation-associated parameters similar to those elicited by the oncogenic v-myc-encoding retrovirus MC29, including alteration of cellular morphology, anchorage-independent growth, and induction of immortalized cell lines. Despite the fact that EF168 and MC29 shared these biological activities, further analysis revealed that EF168 initiated transformation in quail embryo fibroblasts, bone marrow, or adherent peripheral blood cultures 100- to 1,000-fold less efficiently than did MC29. Further, in contrast to MC29-induced foci, EF168 foci were smaller, morphologically diffuse, and less prominent. Analysis of newly infected cells demonstrated efficient expression of EF168 viral RNA in the absence of transformation. These differences suggest that while the pp59v-myc gene product can exert dominant transforming activity on quail embryo fibroblasts, its ability to initiate transformation is distinct from that of the pp110gag-v-myc gene product encoded by MC29 and may be suppressed by adjacent nontransformed cell neighbors.
Starting Page	6621
File Format	PDF
ISSN	10985514
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	12
Volume Number	65
Language	English
Publisher Date	1991-12-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

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