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| Content Provider | PubMed Central |
|---|---|
| Author | Mayo, Joseph W. Anderson, R. L. |
| Abstract | Growth of Aerobacter aerogenes PRL-R3 on the unnatural hexose l-mannose as a sole carbon source is dependent upon the selection of a mutant. Growth of the mutant on l-mannose did not require the synthesis of novel enzymes for the degradation of l-mannose, since enzymes of the l-rhamnose degradative pathway could serve this function. However, unlike most other apparent gain mutations that have been described, the mutant was not constitutive for the degradative enzymes; isomerase, kinase, and aldolase activities functional in the degradation of both l-mannose and l-rhamnose were induced by either of these hexoses in the wild type as well as in the mutant. The fact that the wild type could metabolize l-mannose also ruled out the possibility that the cells were not permeable to l-mannose. Growth of the wild type on nutrient broth was severely inhibited by l-mannose coincident with the onset of l-mannose metabolism. A similar inhibition of growth of the mutant was overcome in about 2 hr. Both strains utilized l-rhamnose and l-mannose sequentially in a mineral medium containing both of these hexoses; at the onset of l-mannose metabolism, growth of the wild type, but not of the mutant, was inhibited. Thus, wild-type A. aerogenes cannot grow on l-mannose because of the toxicity of l-mannose or its metabolites. A mutation which overcomes the toxicity enables the organism to utilize l-mannose as a sole source of carbon and energy for growth. |
| Starting Page | 948 |
| File Format | |
| ISSN | 10985530 |
| e-ISSN | 10985530 |
| Journal | Journal of Bacteriology |
| Issue Number | 2 |
| Volume Number | 100 |
| Language | English |
| Publisher Date | 1969-11-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Molecular Biology Microbiology |
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