NDLI: Parallel memory processing by the CA1 region of the dorsal hippocampus and the basolateral amygdala

Content Provider	PubMed Central
Author	Cammarota, Martín Bevilaqua, Lia R. Rossato, Janine I. Lima, Ramón H. Medina, Jorge H. Izquierdo, Iván
Abstract	There is abundant literature on the role of the basolateral amygdala (BLA) and the CA1 region of the hippocampus in memory formation of inhibitory avoidance (IA) and other behaviorally arousing tasks. Here, we investigate molecular correlates of IA consolidation in the two structures and their relation to NMDA receptors (NMDArs) and β-adrenergic receptors (β-ADrs). The separate posttraining administration of antagonists of NMDAr and β-ADr to BLA and CA1 is amnesic. IA training is followed by an increase of the phosphorylation of calcium and calmodulin-dependent protein kinase II (CaMKII) and ERK2 in CA1 but only an increase of the phosphorylation of ERK2 in BLA. The changes are blocked by NMDAr antagonists but not β-ADr antagonists in CA1, and they are blocked by β-ADr but not NMDAr antagonists in BLA. In addition, the changes are accompanied by increased phosphorylation of tyrosine hydroxylase in BLA but not in CA1, suggesting that β-AD modulation results from local catecholamine synthesis in the former but not in the latter structure. NMDAr blockers in CA1 do not alter the learning-induced neurochemical changes in BLA, and β-ADr blockade in BLA does not hinder those in CA1. When put together with other data from the literature, the present findings suggest that CA1 and BLA play a role in consolidation, but they operate to an extent in parallel, suggesting that each is probably involved with different aspects of the task studied.
Related Links	http://dx.doi.org/10.1073/pnas.0805284105
Ending Page	10284
Page Count	6
Starting Page	10279
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	30
Volume Number	105
Language	English
Publisher	National Academy of Sciences
Publisher Date	2008-07-29
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A Conditioning-Strengthened Circuit From CA1 of Dorsal Hippocampus to Basolateral Amygdala Participates in Morphine-Withdrawal Memory Retrieval

Major neurotransmitter systems in dorsal hippocampus and basolateral amygdala control social recognition memory

The molecular cascades of long-term potentiation underlie memory consolidation of one-trial avoidance in the CA1 region of the dorsal hippocampus, but not in the basolateral amygdala or the neocortex

The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: Dependence on the basolateral amygdala

Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus

Histamine in the basolateral amygdala promotes inhibitory avoidance learning independently of hippocampus.

Differential involvement of the hippocampus, anterior cingulate cortex, and basolateral amygdala in memory for context and footshock

Histamine in the basolateral amygdala promotes inhibitory avoidance learning independently of hippocampus

Resilience and Vulnerability to Trauma: Early Life Interventions Modulate Aversive Memory Reconsolidation in the Dorsal Hippocampus

Parallel memory processing by the CA1 region of the dorsal hippocampus and the basolateral amygdala

Similar Documents

A Conditioning-Strengthened Circuit From CA1 of Dorsal Hippocampus to Basolateral Amygdala Participates in Morphine-Withdrawal Memory Retrieval

Major neurotransmitter systems in dorsal hippocampus and basolateral amygdala control social recognition memory

The molecular cascades of long-term potentiation underlie memory consolidation of one-trial avoidance in the CA1 region of the dorsal hippocampus, but not in the basolateral amygdala or the neocortex

The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: Dependence on the basolateral amygdala

Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus

Histamine in the basolateral amygdala promotes inhibitory avoidance learning independently of hippocampus.

Differential involvement of the hippocampus, anterior cingulate cortex, and basolateral amygdala in memory for context and footshock

Histamine in the basolateral amygdala promotes inhibitory avoidance learning independently of hippocampus

Resilience and Vulnerability to Trauma: Early Life Interventions Modulate Aversive Memory Reconsolidation in the Dorsal Hippocampus

Parallel memory processing by the CA1 region of the dorsal hippocampus and the basolateral amygdala