NDLI: Linker insertion mutations in the adenovirus preterminal protein that affect DNA replication activity in vivo and in vitro.

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Deletions in the tRNA(Lys) primer-binding site of human immunodeficiency virus type 1 identify essential regions for reverse transcription.

Enzymatic activity of poliovirus RNA polymerase mutants with single amino acid changes in the conserved YGDD amino acid motif.

Proteolytic processing of pol-TYB proteins from the yeast retrotransposon Ty1.

In vivo accumulation of a turnip crinkle virus defective interfering RNA is affected by alterations in size and sequence.

Linker insertion mutations in the adenovirus preterminal protein that affect DNA replication activity in vivo and in vitro.

Sequence analysis, expression, and deletion of a vaccinia virus gene encoding a homolog of profilin, a eukaryotic actin-binding protein.

Utilization of DNA recombination for the two-step replacement of growth factor sequences in the vaccinia virus genome.

Characterization of endogenous and recombinant proviral elements of a highly tumorigenic AKR cell line.

The minute virus of mice capsid specifically recognizes the 3' hairpin structure of the viral replicative-form DNA: mapping of the binding site by hydroxyl radical footprinting.

Human immunodeficiency virus integrase protein requires a subterminal position of its viral DNA recognition sequence for efficient cleavage.

Oscillation of the human immunodeficiency virus surface receptor is regulated by the state of viral activation in a CD4+ cell model of chronic infection.

Identification of antigenically important domains in the glycoproteins of Sindbis virus by analysis of antibody escape variants.

Genetic analysis of the DNA recognition sequence of the P2 Cox protein.

Characterization of the DNA polymerase gene of human herpesvirus 6.

Identification of T- and B-cell epitopes of the E7 protein of human papillomavirus type 16.

A single point mutation activates the Moloney murine leukemia virus long terminal repeat in embryonal stem cells.

Identification of the hepatitis B virus factor that inhibits expression of the beta interferon gene.

Hog cholera virus: molecular composition of virions from a pestivirus.

Molecular cloning and characterization of a complete Chinese hamster provirus related to intracisternal A particle genomes.

Rotavirus protein rearrangements in purified membrane-enveloped intermediate particles.

Production of polyomavirus late mRNAs requires sequences near the 5' end of the leader but does not require leader-to-leader splicing.

RGD-dependent entry of coxsackievirus A9 into host cells and its bypass after cleavage of VP1 protein by intestinal proteases.

Host-derived 5' ends and overlapping complementary 3' ends of the two mRNAs transcribed from the ambisense S segment of Uukuniemi virus.

Flavivirus enzyme-substrate interactions studied with chimeric proteinases: identification of an intragenic locus important for substrate recognition.

Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes.

Spleen necrosis virus, an avian retrovirus, can infect primate cells.

Recombinant CD4-selected human immunodeficiency virus type 1 variants with reduced gp120 affinity for CD4 and increased cell fusion capacity.

Characterization of large deletions occurring during a single round of retrovirus vector replication: novel deletion mechanism involving errors in strand transfer.

Complex regulation of transcription from the hepatitis B virus major surface antigen promoter in human hepatoma cell lines.

Fine specificity of cellular immune responses in humans to human cytomegalovirus immediate-early 1 protein.

Synthesis and characterization of chimeric particles between epizootic hemorrhagic disease virus and bluetongue virus: functional domains are conserved on the VP3 protein.

Epitope mapping of two immunodominant domains of gp41, the transmembrane protein of human immunodeficiency virus type 1, using ten human monoclonal antibodies.

Endogenous interferon specifically regulates Newcastle disease virus-induced cytokine gene expression in mouse macrophages.

Generation of hybrid human immunodeficiency virus utilizing the cotransfection method and analysis of cellular tropism.

Reversible conformational changes and fusion activity of rabies virus glycoprotein.

The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture.

Nucleotide sequences important for translation initiation of enterovirus RNA.

Mouse DNA primase plays the principal role in determination of permissiveness for polyomavirus DNA replication.

Mutations responsible for adaptation of hepatitis A virus to efficient growth in cell culture.

Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors.

Several CD4 domains can play a role in human immunodeficiency virus infection in cells.

Replication of an acutely lethal simian immunodeficiency virus activates and induces proliferation of lymphocytes.

Transcriptional elongation by purified RNA polymerase II is blocked at the trans-activation-responsive region of human immunodeficiency virus type 1 in vitro.

Initiation of transcription from the minute virus of mice P4 promoter is stimulated in rat cells expressing a c-Ha-ras oncogene.

Activation of the c-ski oncogene by overexpression.

Respiratory syncytial virus infection in anti-mu-treated mice.

Biological properties of the deer papillomavirus E5 gene in mouse C127 cells: growth transformation, induction of DNA synthesis, and activation of the platelet-derived growth factor receptor.

Murine infection by vesicular stomatitis virus: initial characterization of the H-2d system.

Episodic occurrence of antibodies against the bovine leukemia virus Rex protein during the course of infection in sheep.

Purification and characterization of human papillomavirus type 16 E7 protein with preferential binding capacity to the underphosphorylated form of retinoblastoma gene product.

Specific mutation of a regulatory site within the ATP-binding region of simian virus 40 large T antigen.

Internal initiation of translation in retroviral vectors carrying picornavirus 5' nontranslated regions.

Nuclear assembly of polyomavirus capsids in insect cells expressing the major capsid protein VP1.

Neutralization map of the hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus: domains recognized by monoclonal antibodies that prevent receptor recognition.

Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity.

Infection by coronavirus JHM of rat neurons and oligodendrocyte-type-2 astrocyte lineage cells during distinct developmental stages.

The hepatitis A virus polyprotein expressed by a recombinant vaccinia virus undergoes proteolytic processing and assembly into viruslike particles.

Identification of two distinct regions within the adenovirus minimal origin of replication that are required for adenovirus type 4 DNA replication in vitro.

In vivo activation of human immunodeficiency virus type 1 long terminal repeat by UV type A (UV-A) light plus psoralen and UV-B light in the skin of transgenic mice.

Antibody enhancement of respiratory syncytial virus stimulation of leukotriene production by a macrophagelike cell line.

Isolation, identification, and partial cDNA cloning of genomic RNA of jaagsiekte retrovirus, the etiological agent of sheep pulmonary adenomatosis.

Localization of immunogenic domains in the human immunodeficiency virus type 2 envelope.

Proteolytic conversion of hepatitis B virus e antigen precursor to end product occurs in a postendoplasmic reticulum compartment.

Cooperative binding of EF-1A to the E1A enhancer region mediates synergistic effects on E1A transcription during adenovirus infection.

The vpx gene of simian immunodeficiency virus facilitates efficient viral replication in fresh lymphocytes and macrophage.

Prevalence of the archetypal regulatory region and sequence polymorphisms in nonpassaged BK virus variants.

Cytopathic variants of an attenuated isolate of human immunodeficiency virus type 2 exhibit increased affinity for CD4.

The Lang strain of reovirus serotype 1 and the Dearing strain of reovirus serotype 3 differ in their sensitivities to beta interferon.

Human herpesvirus 6 induces interleukin-1 beta and tumor necrosis factor alpha, but not interleukin-6, in peripheral blood mononuclear cell cultures.

Overexpression of the gag-pol precursor from human immunodeficiency virus type 1 proviral genomes results in efficient proteolytic processing in the absence of virion production.

A nested set of eight RNAs is formed in macrophages infected with lactate dehydrogenase-elevating virus.

Anti-idiotype antibodies that mimic gp86 of human cytomegalovirus inhibit viral fusion but not attachment.

Host Range Specificity of Polyomavirus EC Mutants in Mouse Embryonal Carcinoma and Embryonal Stem Cells and Preimplantation Embryos

Heterotypic Passive Protection Induced by Synthetic Peptides Corresponding to VP7 and VP4 of Bovine Rotavirus

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Linker insertion mutations in the adenovirus preterminal protein that affect DNA replication activity in vivo and in vitro.

Content Provider	PubMed Central
Author	Fredman, J. N. Pettit, S. C. Horwitz, M. S. Engler, J. A.
Abstract	Eighteen linker insertion mutants with mutations in the adenovirus precursor to terminal protein (pTP), which were originally constructed and tested in virions by Freimuth and Ginsberg (Proc. Natl. Acad. Sci. USA 83:7816-7820, 1986), were transferred to expression plasmids for assay of the various functions of the isolated pTP. Function was measured by the ability of individual pTP mutant proteins to participate in the initiation of replication from an adenovirus DNA end, by their activity in assays of DNA elongation, and by the intracellular distribution of pTP demonstrated by indirect immunofluorescence. Ten of the 11 mutants that were active in virion formation were also functional in DNA replication reactions in extracts, while 1 had reduced function. Four mutants with mutations that were lethal to virus production were also inactive in DNA replication reactions. These four mutations are probably located at sites required for the function of pTP in DNA synthesis. Three pTP mutants with mutations that were lethal or partially defective with respect to virion formation were active in reactions requiring pTP for initiation and elongation in extracts. All three of these mutant pTPs targeted normally to the nucleus, suggesting a defect after this step in replication. Since pTP has been reported to bind the nuclear matrix, these pTP mutants may have mutations that define sites necessary for binding to this structure. Several mutants with mutations that lie outside the putative nuclear targeting region were aberrantly localized, suggesting either that additional domains are important in nuclear localization or that there are alterations in protein structure that affect nuclear transport for some pTP mutants.
Starting Page	4591
File Format	PDF
ISSN	10985514
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	9
Volume Number	65
Language	English
Publisher Date	1991-09-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

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