NDLI: Realistic modeling of entorhinal cortex field potentials and interpretation of epileptic activity in the guinea pig isolated brain preparation

Content Provider	PubMed Central
Author	Etienne, Labyt Uva, Laura Curtis, Marco De Wendling, Fabrice
Abstract	Mechanisms underlying epileptic activities recorded from entorhinal cortex (EC) were studied through a computational model based on review of cytoarchitectonic and neurobiological data about this structure. The purpose of this study is to describe and use this model to interpret epileptiform discharge patterns recorded in an experimental model of ictogenesis (guinea-pig isolated brain perfused with bicuculline). A macroscopic modeling approach representing synaptic interactions between cells subpopulations in the EC was chosen for its adequacy to mimic field potentials reflecting overall dynamics rising from interconnected cells populations. Therefore, intrinsic properties of neurons were not included in the modeling design. Model parameters were adjusted from an identification procedure based on quantitative comparison between real and simulated signals. For both EC deep and superficial layers, results show that the model generates very realistic signals regarding temporal dynamics, spectral features and cross-correlation values. These simulations allowed us to infer information about the evolution of synaptic transmission between principal cell and interneuronal populations and about connectivity between deep and superficial layers during the transition from background to ictal activity. In the model, this transition was obtained for increased excitation in deep versus superficial layers. Transitions between epileptiform activities (interictal spikes, fast onset activity (25Hz), ictal bursting activity) were explained by changes of parameters mainly related to GABAergic interactions. Notably, the model predicted an important role of GABAa,fast and GABAb receptor-mediated inhibition in the generation of ictal fast onset and burst activities, respectively. These findings are discussed with respect to experimental data.
Related Links	http://dx.doi.org/10.1152/jn.01342.2005
Ending Page	377
Page Count	15
Starting Page	363
File Format	PDF
ISSN	00223077
e-ISSN	15221598
Journal	Journal of Neurophysiology
Issue Number	1
Volume Number	96
Language	English
Publisher	American Physiological Society
Publisher Date	2006-03-01
Access Restriction	Open
Rights Holder	American Physiological Society
Subject Keyword	Physiology Neuroscience(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Physiology

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