NDLI: Enhanced viral immunoinflammatory lesions in mice lacking IL-23 responses

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Enhanced viral immunoinflammatory lesions in mice lacking IL-23 responses

Content Provider	PubMed Central
Author	Kim, Bumseok Sarangi, Pranita P. Azkur, Ahmet Kursat Deshpande, Kaistha Shilpa Rouse, Barry T.
Abstract	Herpes simplex virus (HSV) infection of the cornea culminates in an immunopathological lesion (stromal keratitis - SK) that impairs vision. This report shows that HSV infection results in IL-23 up-regulation, but if this response fails to occur, as was noted in p19-/- mice, the severity of lesions, their incidence and the level of viral induced angiogenesis were significantly increased compared to wild-type (WT) animals (p < 0.05). The higher disease severity in p19-/- mice appeared to be the consequence of an increased IL-12 response that in turn led to the induction of higher numbers of IFN-γ producing CD4+ T cells, the principal orchestrators of SK. Our results indicate that the severity of HSV induced immunopathological lesions may be mainly the consequence of IL-12 driven Th1 T cell reactions rather than the action of IL-17 producing cells controlled by IL-23.
Related Links	http://dx.doi.org/10.1016/j.micinf.2007.12.007
Starting Page	302
File Format	PDF
ISSN	12864579
Journal	Microbes and infection / Institut Pasteur
Issue Number	3
Volume Number	10
Language	English
Publisher Date	2008-03-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Immunology Microbiology

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