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| Content Provider | PubMed Central |
|---|---|
| Author | Yoshida, Takumi Sugiura, Hidekazu Mitobe, Michihiro Tsuchiya, Ken Shirota, Satsuki Nishimura, Sayoko Shiohira, Shunji Ito, Hiroshi Kiyoshi, Nobori Gullans, Steven R. Akiba, Takashi Nitta, Kosaku |
| Abstract | Oxidative stress-induced cell death plays a major role in the progression of ischemic acute renal failure. Using microarrays, we sought to identify a stress-induced gene that may be a therapeutic candidate. Human proximal tubule (HK2) cells were treated with hydrogen peroxide (H2O2) and RNA was applied to an Affymetrix gene chip. Five genes were markedly induced in a parallel time-dependent manner by cluster analysis, including activating transcription factor 3 (ATF3), p21WAF1/CiP1 (p21), CHOP/GADD153, dual-specificity protein phosphatase, and heme oxygenase-1. H2O2 rapidly induced ATF3 approximately 12-fold in HK2 cells and approximately 6.5-fold in a mouse model of renal ischemia-reperfusion injury. Adenovirus-mediated expression of ATF3 protected HK2 cells against H2O2-induced cell death, and this was associated with a decrease of p53 mRNA and an increase of p21 mRNA. Moreover, when ATF3 was overexpressed in mice via adenovirus-mediated gene transfer, ischemia-reperfusion injury was reduced. In conclusion, ATF3 plays a protective role in renal ischemia-reperfusion injury and the mechanism of the protection may involve suppression of p53 and induction of p21. |
| Related Links | http://dx.doi.org/10.1681/asn.2005111155 |
| Ending Page | 224 |
| Page Count | 8 |
| Starting Page | 217 |
| File Format | |
| ISSN | 10466673 |
| e-ISSN | 15333450 |
| Journal | Journal of the American Society of Nephrology : JASN |
| Issue Number | 2 |
| Volume Number | 19 |
| Language | English |
| Publisher | American Society of Nephrology |
| Publisher Date | 2008-01-01 |
| Access Restriction | Open |
| Rights Holder | American Society of Nephrology |
| Subject Keyword | Nephrology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nephrology |
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