NDLI: Boolean network models of cellular regulation: prospects and limitations

Content Provider	PubMed Central
Author	Bornholdt, Stefan
Copyright Year	2008
Abstract	Computer models are valuable tools towards an understanding of the cell's biochemical regulatory machinery. Possible levels of description of such models range from modelling the underlying biochemical details to top-down approaches, using tools from the theory of complex networks. The latter, coarse-grained approach is taken where regulatory circuits are classified in graph-theoretical terms, with the elements of the regulatory networks being reduced to simply nodes and links, in order to obtain architectural information about the network. Further, considering dynamics on networks at such an abstract level seems rather unlikely to match dynamical regulatory activity of biological cells. Therefore, it came as a surprise when recently examples of discrete dynamical network models based on very simplistic dynamical elements emerged which in fact do match sequences of regulatory patterns of their biological counterparts. Here I will review such discrete dynamical network models, or Boolean networks, of biological regulatory networks. Further, we will take a look at such models extended with stochastic noise, which allow studying the role of network topology in providing robustness against noise. In the end, we will discuss the interesting question of why at all such simple models can describe aspects of biology despite their simplicity. Finally, prospects of Boolean models in exploratory dynamical models for biological circuits and their mutants will be discussed.
Related Links	http://dx.doi.org/10.1098/rsif.2008.0132.focus
Starting Page	85
File Format	PDF
ISSN	17425662
e-ISSN	17425662
Journal	Journal of the Royal Society Interface
Issue Number	Suppl 1
Volume Number	5
Language	English
Publisher	The Royal Society
Publisher Date	2008-08-06
Access Restriction	Open
Rights Holder	The Royal Society
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biochemistry Biomaterials Biophysics Bioengineering Biomedical Engineering Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Boolean network models of cellular regulation: prospects and limitations

Digital clocks: simple Boolean models can quantitatively describe circadian systems

Network-based vaccination improves prospects for disease control in wild chimpanzees

Corrigendum for the paper ‘Digital clocks: simple Boolean models can quantitatively describe circadian systems’

Autonomous Boolean modelling of developmental gene regulatory networks

Synthetic biology: history, challenges and prospects

When individual behaviour matters: homogeneous and network models in epidemiology

Spatio-temporal waves and targeted vaccination in recurrent epidemic network models

Biomolecular simulation and modelling: status, progress and prospects

Boolean network models of cellular regulation: prospects and limitations

Similar Documents

Boolean network models of cellular regulation: prospects and limitations

Digital clocks: simple Boolean models can quantitatively describe circadian systems

Network-based vaccination improves prospects for disease control in wild chimpanzees

Corrigendum for the paper ‘Digital clocks: simple Boolean models can quantitatively describe circadian systems’

Autonomous Boolean modelling of developmental gene regulatory networks

Synthetic biology: history, challenges and prospects

When individual behaviour matters: homogeneous and network models in epidemiology

Spatio-temporal waves and targeted vaccination in recurrent epidemic network models

Biomolecular simulation and modelling: status, progress and prospects

Boolean network models of cellular regulation: prospects and limitations