NDLI: Immunization of mice with vaccinia virus-M2 recombinant induces epitope-specific and cross-reactive Kd-restricted CD8+ cytotoxic T cells.

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Encapsidation of genetically engineered poliovirus minireplicons which express human immunodeficiency virus type 1 Gag and Pol proteins upon infection.

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A single nucleotide substitution in the internal ribosome entry site of foot-and-mouth disease virus leads to enhanced cap-independent translation in vivo.

Precore-mediated inhibition of hepatitis B virus progeny DNA synthesis.

A direct demonstration of recombination between an injected virus and endogenous viral sequences, resulting in the generation of mink cell focus-inducing viruses in AKR mice.

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La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate.

Molecular characterization of mouse-virulent poliovirus type 1 Mahoney mutants: involvement of residues of polypeptides VP1 and VP2 located on the inner surface of the capsid protein shell.

Physicochemical dissociation of CD4-mediated syncytium formation and shedding of human immunodeficiency virus type 1 gp120.

Analysis of deletions and thermosensitive mutations in Rous sarcoma virus gag protein p10.

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Assembly of Theiler's virus recombinants used in mapping determinants of neurovirulence.

Gene mapping and expression of two immunodominant Epstein-Barr virus capsid proteins.

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Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus.

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Packaging of human immunodeficiency virus type 1 RNA requires cis-acting sequences outside the 5' leader region.

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Immunization of mice with vaccinia virus-M2 recombinant induces epitope-specific and cross-reactive Kd-restricted CD8+ cytotoxic T cells.

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Murine cytomegalovirus interacts with major histocompatibility complex class I molecules to establish cellular infection.

Human immunodeficiency virus type 1 Vpu has a CD4- and an envelope glycoprotein-independent function.

Repression of RNA polymerase III transcription by adenovirus E1A.

Differential expression of Rel family members in human T-cell leukemia virus type I-infected cells: transcriptional activation of c-rel by Tax protein.

Importance of interferons in recovery from mousepox.

Biochemical analysis of mutants with changes in the origin-binding domain of simian virus 40 tumor antigen.

cis-acting elements in the lytic origin of DNA replication of Epstein-Barr virus.

The transcriptional activation domain of varicella-zoster virus open reading frame 62 protein is not conserved with its herpes simplex virus homolog.

trans processing of vaccinia virus core proteins.

Assembly, processing, and infectivity of human immunodeficiency virus type 1 gag mutants.

Vectorial release of poliovirus from polarized human intestinal epithelial cells.

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Chimeric cDNA studies of Theiler's murine encephalomyelitis virus neurovirulence.

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Viral liposomes released from insect cells infected with recombinant baculovirus expressing the matrix protein of vesicular stomatitis virus.

Differential contribution of herpes simplex virus type 1 gene products and cellular factors to the activation of human immunodeficiency virus type 1 provirus.

Identification of a region of the poliovirus genome involved in persistent infection of HEp-2 cells.

Phorbol esters modulate the phosphorylation of human T-cell leukemia virus type I Tax.

Analysis of the terminal repeat binding abilities of mutant adeno-associated virus replication proteins.

Differential regulation of the human immunodeficiency virus type 2 enhancer in monocytes at various stages of differentiation.

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Immunization of mice with vaccinia virus-M2 recombinant induces epitope-specific and cross-reactive Kd-restricted CD8+ cytotoxic T cells.

Content Provider	PubMed Central
Author	Kulkarni, A. B. Morse, H. C. Bennink, J. R. Yewdell, J. W. Murphy, B. R.
Abstract	The M2 protein of respiratory syncytial virus (RSV) is a protective antigen in H-2d, but not H-2b or H-2k mice. None of the other RSV proteins, excluding the surface glycoproteins that induce neutralizing antibodies, is protective in mice bearing these haplotypes. Thus, the M2 protein stands alone as a nonglycoprotein-protective antigen of RSV. The M2 protein is a target for murine Kd-restricted cytotoxic T lymphocytes (CTLs), and the resistance induced by infection with a vaccinia virus-RSV M2 (vac-M2) recombinant is mediated by CD8+ CTLs. Since the nonameric consensus sequence for H-2 Kd-restricted T-cell epitopes and the amino acid sequence of the M2 protein of subgroup A and B strains of RSV are known, the present study sought to identify the specific epitope(s) on the M2 protein recognized by CD8+ CTLs. This was done by examining the ability of four predicted Kd-specific motif peptides present in the M2 amino acid sequence of an RSV subgroup A strain to sensitize target cells for lysis by pulmonary or splenic CTLs obtained from mice infected with RSV or vac-M2. The following observations were made. First, two of the four peptides sensitized target cells for lysis by pulmonary or splenic CTLs induced by infection with either vac-M2 or RSV. Second, one of the two peptides, namely the 82-90 (M2) peptide, sensitized targets at a very low peptide concentration (10(-10) to 10(-12) M). Third, cold-target competition experiments revealed that the predominant CTL population induced by infection with vac-M2 or RSV recognized the 82-90 (M2) peptide, and this CTL population appeared to recognize the 71-79 (M2) peptide in a cross-reactive manner. Fourth, CTL recognition of targets sensitized with either the 71-79 (M2) or the 82-90 (M2) peptide was Kd restricted. Fifth, CTLs induced by infection with RSV subgroup A or B strains recognized the two M2 peptides. The findings suggest that the M2 protein of RSV contains an immunodominant Kd-restricted CTL epitope consisting of amino acid residues 82 to 90 (SYIGSINNI), which are shared by subgroup A and B RSVs.
Starting Page	4086
File Format	PDF
ISSN	10985514
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	7
Volume Number	67
Language	English
Publisher Date	1993-07-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

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