NDLI: Pathological changes in platelet histamine oxidases in atopic eczema

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Pathological changes in platelet histamine oxidases in atopic eczema

Content Provider	PubMed Central
Author	Kiehl, Reinhold Ionescu, Gruia
Copyright Year	1993
Abstract	Increased plasma histamine levels were associated with significantly lowered diamine and type B monoamine oxidase activities in platelet-rich plasma of atopic eczema (AE) patients. The diamine oxidase has almost normal cofactor levels (pyridoxal phosphate and Cu2+) but the cofactor levels for type B monoamine oxidase (flavin adenine dinucleotide and Fe2+) are lowered. The biogenic amines putrescine, cadaverine, spermidine, spermine, tyramine and serotonin in the sera, as well as dopamine and epinephrine in EDTA-plasma were found to be normal. It is unlikely, therefore, that these amines are responsible for the decreased activities of monoamine and diamine oxidase in these patients. The most likely causative factors for the inhibition of the diamine oxidase are nicotine, alcohol, food additives and other environmental chemicals, or perhaps a genetic defect of the diamine oxidase.
Related Links	http://dx.doi.org/10.1155/s0962935193000560
Ending Page	406
Page Count	4
Starting Page	403
File Format	PDF
ISSN	09629351
e-ISSN	14661861
Journal	Mediators of Inflammation
Issue Number	6
Volume Number	2
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	1993-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Immunology Cell Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Immunology

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