NDLI: The molecular pathology of p53 in primitive neuroectodermal tumours of the central nervous system

Content Provider	PubMed Central
Author	Burns, A. S. Y. W. Jaros, E. Cole, M. Perry, R. Pearson, A. J. Lunec, J.
Copyright Year	2002
Abstract	One hundred and one pre-treatment primary central primitive neuroectodermal tumours were analysed for the expression of p53 protein by immunohistochemistry using the monoclonal antibody DO-7. The staining intensity was classified into four groups: strong, medium, weak and negative and strong staining intensity was associated with the poorest survival. DNA sequencing of the p53 gene was performed in 28 cases representing all four staining groups. Mutations were found in only three of the strong staining tumours suggesting that DNA mutations were not common events and that in the majority of the tumours with over-expressed p53, the protein was likely to be wild-type. Results of immunohistochemistry showed a significantly positive relationship between the expression of p53 and Bax and Bcl-2 proteins, but not Waf-1. Multivariate analyses supported the prognostic value of p53 immunostaining in central primitive neuroectodermal tumours and also of age and gender of patients.
Related Links	http://dx.doi.org/10.1038/sj.bjc.6600151
Ending Page	1123
Page Count	7
Starting Page	1117
File Format	PDF
ISSN	15321827
e-ISSN	15321827
Journal	British Journal of Cancer
Issue Number	7
Volume Number	86
Language	English
Publisher	Nature Publishing Group
Publisher Date	2002-04-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Cancer Research Oncology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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