NDLI: Lack of DMBT1 expression in oesophageal, gastric and colon cancers

Content Provider	PubMed Central
Author	Mori, M. Shiraishi, T. Tanaka, S. Yamagata, M. Mafune, K. Tanaka, Y. Ueo, H. Barnard, G. F. Sugimachi, K.
Copyright Year	1999
Abstract	Loss of sequences from human chromosome 10q has been reported in several different cancers. Recently, a second candidate tumour-suppressor gene, DMBT1, was identified in this chromosomal region. We studied the mRNA expression and homozygous deletion of this gene in human oesophageal, gastric and colon cancers. Reverse transcriptase polymerase chain reaction (RT-PCR) amplification demonstrated that 23 (53.5%) of 43 oesophageal, 5 (12.5%) of 40 gastric, and 4 (16.7%) of 24 colorectal cancer cases showed an apparent reduction in DMBT1 mRNA in tumour tissues compared with paired normal tissues. Twelve out of 15 oesophageal cancer cell lines also showed no expression. We next studied homozygous deletions within the DMBT1 gene in oesophageal cancers by using duplex PCR. Consequently, it was recognized in five (11.6%) of the primary tumours and two (13.3%) of the cell lines. These findings suggest that DMBT1 may act as a tumour-suppressor gene not only in brain tumours but also in gastrointestinal cancers, especially in oesophageal cancers. © 1999 Cancer Research Campaign
Related Links	http://dx.doi.org/10.1038/sj.bjc.6690035
Ending Page	213
Page Count	3
Starting Page	211
File Format	PDF
ISSN	00070920
e-ISSN	15321827
Journal	British Journal of Cancer
Issue Number	2
Volume Number	79
Language	English
Publisher	Nature Publishing Group
Publisher Date	1999-01-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Cancer Research Oncology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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