NDLI: Precise switching of DNA replication timing in the GC content transition area in the human major histocompatibility complex.

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Analysis of the sorting signals directing NADH-cytochrome b5 reductase to two locations within yeast mitochondria.

Small heat shock protein suppression of Vpr-induced cytoskeletal defects in budding yeast.

Precise switching of DNA replication timing in the GC content transition area in the human major histocompatibility complex.

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Precise switching of DNA replication timing in the GC content transition area in the human major histocompatibility complex.

Content Provider	PubMed Central
Author	Tenzen, T. Yamagata, T. Fukagawa, T. Sugaya, K. Ando, A. Inoko, H. Gojobori, T. Fujiyama, A. Okumura, K. Ikemura, T.
Abstract	The human genome is composed of long-range G+C% (GC%) mosaic structures thought to be related to chromosome bands. We previously reported a boundary of megabase-sized GC% mosaic domains at the junction area between major histocompatibility complex (MHC) classes II and III, proposing it as a possible chromosome band boundary. DNA replication timing during the S phase is known to be correlated cytogenetically with chromosome band zones, and thus the band boundaries have been predicted to contain a switch point for DNA replication timing. In this study, to identify to the nucleotide sequence level the replication switch point during the S phase, we determined the precise DNA replication timing for MHC classes II and III, focusing on the junction area. To do this, we used PCR-based quantitation of nascent DNA obtained from synchronized human myeloid leukemia HL60 cells. The replication timing changed precisely in the boundary region with a 2-h difference between the two sides, supporting the prediction that this region may be a chromosome band boundary. We supposed that replication fork movement terminates (pauses) or significantly slows in the switch region, which contains dense Alu clusters; polypurine/polypyrimidine tracts; di-, tri-, or tetranucleotide repeats; and medium-reiteration-frequency sequences. Because the nascent DNA in the switch region was recovered at low efficiency, we investigated whether this region is associated with the nuclear scaffold and found three scaffold-associated regions in and around the switch region.
Starting Page	4043
File Format	PDF
ISSN	10985549
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	7
Volume Number	17
Language	English
Publisher Date	1997-07-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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