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| Content Provider | PubMed Central |
|---|---|
| Author | Firestein, Ron Blander, Gil Michan, Shaday Philipp, Oberdoerffer Ogino, Shuji Campbell, Jennifer Anupama, Bhimavarapu Sandra, Luikenhuis Cabo, Rafael De Fuchs, Charles Hahn, William C. Guarente, Leonard P. Sinclair, David A. |
| Editor | Blagosklonny, Mikhail V. |
| Copyright Year | 2008 |
| Abstract | Numerous longevity genes have been discovered in model organisms and altering their function results in prolonged lifespan. In mammals, some have speculated that any health benefits derived from manipulating these same pathways might be offset by increased cancer risk on account of their propensity to boost cell survival. The Sir2/SIRT1 family of NAD+-dependent deacetylases is proposed to underlie the health benefits of calorie restriction (CR), a diet that broadly suppresses cancer in mammals. Here we show that CR induces a two-fold increase SIRT1 expression in the intestine of rodents and that ectopic induction of SIRT1 in a β-catenin-driven mouse model of colon cancer significantly reduces tumor formation, proliferation, and animal morbidity in the absence of CR. We show that SIRT1 deacetylates β-catenin and suppresses its ability to activate transcription and drive cell proliferation. Moreover, SIRT1 promotes cytoplasmic localization of the otherwise nuclear-localized oncogenic form of β-catenin. Consistent with this, a significant inverse correlation was found between the presence of nuclear SIRT1 and the oncogenic form of β−catenin in 81 human colon tumor specimens analyzed. Taken together, these observations show that SIRT1 suppresses intestinal tumor formation in vivo and raise the prospect that therapies targeting SIRT1 may be of clinical use in β−catenin-driven malignancies. |
| Related Links | http://dx.doi.org/10.1371/journal.pone.0002020 |
| Starting Page | 2020 |
| File Format | |
| ISSN | 19326203 |
| e-ISSN | 19326203 |
| Journal | PLoS ONE |
| Issue Number | 4 |
| Volume Number | 3 |
| Language | English |
| Publisher | Public Library of Science |
| Publisher Date | 2008-04-01 |
| Access Restriction | Open |
| Rights Holder | Public Library of Science |
| Subject Keyword | Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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