NDLI: Evidence for the presence of a novel Kv4-mediated A-type K+ channel-modifying factor

Content Provider	PubMed Central
Author	Nadal, Marcela S. Amarillo, Yimy Miera, Eleazar Vega-saenz De Rudy, Bernardo
Copyright Year	2001
Abstract	Subthreshold-operating transient (A-type) K+ currents (I SAs) are important in regulating neuronal firing frequency and in the modulation of incoming signals in dendrites. It is now known that Kv4 proteins are the principal, or pore-forming, subunits of the channels mediating I SAs. In addition, accessory subunits of Kv4 channels have also been identified. These either have no effect or slow down the inactivation kinetics of Kv4 channels. However, in many neuronal populations the I SA is faster, not slower, than the current generated by channels containing only Kv4 proteins. Evidence is presented for the presence in rat cerebellar mRNA of transcripts encoding a molecular factor, termed KAF, that accelerates the kinetics of Kv4 channels. Size-fractionation of cerebellar mRNA in sucrose gradients separated the high molecular weight mRNAs (4–7 kb) encoding KAF from the low molecular weight ones (1.5–3 kb) encoding factors that slow down the inactivation kinetics of Kv4 channels. The latter were identified as KChIPs using anti-KChIP antisense oligonucleotides. Both anti-KChIP and anti-Kv4 antisense oligonucleotides failed to eliminate KAF's activity from the high molecular weight mRNA fraction, thus suggesting that KAF might be a novel subunit(s) that can contribute to generating native I SA channel diversity. The time course of the currents expressed by KAF-modified Kv4 channels resembles more closely the time course of the native I SA in cerebellar granule cells.
Related Links	http://dx.doi.org/10.1111/j.1469-7793.2001.00801.x
Ending Page	809
Page Count	9
Starting Page	801
File Format	PDF
ISSN	00223751
e-ISSN	14697793
Journal	The Journal of Physiology
Issue Number	Pt 3
Volume Number	537
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2001-12-15
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

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