NDLI: Heterogeneous susceptibility of GABAA receptor-mediated IPSCs to depolarization-induced suppression of inhibition in rat hippocampus

Content Provider	PubMed Central
Author	Martin, L. A. Wei, D-s Alger, B. E.
Copyright Year	2001
Abstract	Depolarization-induced suppression of inhibition (DSI) in central neurons is mediated by a transient reduction of γ-aminobutyric acid (GABA) release from interneurons. DSI is induced by a retrograde signal emitted from principal cells. We used electrophysiological recordings from CA1 neurons of the rat hippocampal slice to test the hypothesis that only certain classes of interneurons are susceptible to DSI. DSI of action potential-dependent, spontaneous, inhibitory postsynaptic currents (sIPSCs) in hippocampus is facilitated by carbachol (3 μm), which increases the occurrence of large sIPSCs. Besides carbachol, noradrenaline (norepinephrine; 10 μm), or elevated extracellular potassium (8 mm), could abruptly increase the occurrence of large sIPSCs and DSI in many cases. DSI appeared and disappeared concomitantly with the onset and offset of these large sIPSCs. In contrast, application of AP-5 and CNQX often markedly increased baseline sIPSC activity without enhancing DSI. A brief train of extracellular electrical stimulation could trigger the onset of prolonged, repetitive IPSC activity that was susceptible to DSI. The magnitude of DSI of single evoked IPSCs (eIPSCs) in a given pyramidal cell could be altered by changes in stimulus strength, but there was no simple relationship between stimulus strength and DSI. Baclofen (0.5-5 μm) eliminated the increase in sIPSC activity and DSI induced by carbachol. A GABAB receptor antagonist, CGP 35348, reversed the effects of baclofen. Carbachol-induced sIPSCs had relatively rapid rise and decay phases. There was no marked distinction between DSI-susceptible and non-susceptible sIPSCs. Nevertheless, two kinetically distinct components of the eIPSC could be distinguished by their decay times. DSI reduced GABAA,fast without affecting GABAA,slow. Furosemide (frusemide), which blocks only GABAA,fast, reduced the eIPSC and occluded DSI. The data suggest that, with respect to DSI, there are at least three functionally distinct types of IPSCs. Two types (one susceptible to DSI and one not) have relatively rapid kinetics are probably made by perisomatic synapses. A third, slow IPSC, which is insensitive to DSI, may be produced by distal dendritic synapses.
Related Links	http://dx.doi.org/10.1111/j.1469-7793.2001.0685e.x
Ending Page	700
Page Count	16
Starting Page	685
File Format	PDF
ISSN	00223751
e-ISSN	14697793
Journal	The Journal of Physiology
Issue Number	Pt 3
Volume Number	532
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2001-05-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

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